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cis-Urocanic acid is a 5-HT2A receptor agonist. It binds to the 5-HT receptor with relatively high affinity (Kd=4.6 nM) and acts as an immune modulator, inducing immunosuppression by binding to the 5-HT2A receptor.
Target: 5-HT Receptor
Pathway: GPCR/G Protein; Neuronal Signaling
In vitro activity: Treatment with 100 μg/mL cis-Urocanic acid completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation.
Cell lines for assays: Human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs)
Concentrations for assays: 10, 100, 1,000, and 5,000 μg/mL
Incubation time for assays: 24, 48, or 72 hours
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