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Medchemexpress LLC (Z)-Urocanic acid; cis-UCA | 7699-35-6 | 99.9% | 138.12 | 1 ML
Supplier: Medchemexpress LLC HY113008A10MM/1ML
cis-Urocanic acid is a 5-HT2A receptor agonist. It binds to the 5-HT receptor with relatively high affinity (Kd=4.6 nM) and acts as an immune modulator, inducing immunosuppression by binding to the 5-HT2A receptor.
- Target: 5-HT Receptor
- Pathway: GPCR/G Protein; Neuronal Signaling
- In vitro activity: Treatment with 100 μg/mL cis-Urocanic acid completely suppresses IL-6 and IL-8 secretion, decreases caspase-3 activity, and improves cell viability against UV-B irradiation.
- Cell lines for assays: Human corneal epithelial cells (HCE-2) and human conjunctival epithelial cells (HCECs)
- Concentrations for assays: 10, 100, 1,000, and 5,000 μg/mL
- Incubation time for assays: 24, 48, or 72 hours
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