Oxazoles
Apexbio Technology LLC Y-320 288250-47-5 2mg
Y-320 (CAS 288250-47-5) is a phenylpyrazoleanilide small molecule immunomodulator that inhibits interleukin-17 (IL-17) production in CD4 T cells stimulated by IL-15 exhibiting an IC50 of 20 60 nM In vivo oral administration of Y-320 (0 3 3 mg/kg) reduces IL-17 mRNA expression and suppresses the progression of collagen-induced arthritis (CIA) in mice with additional efficacy observed in cynomolgus monkey CIA models Combination with anti-TNF- monoclonal antibody yields a synergistic effect Y-320 serves as a valuable tool for studying IL-17-mediated inflammatory pathways and for preclinical research in rheumatoid arthritis and related autoimmune diseases
Apexbio Technology LLC Y-320 288250-47-5 10mM (in 1mL DMSO)
Y-320 (CAS 288250-47-5) is a phenylpyrazoleanilide small molecule immunomodulator that inhibits interleukin-17 (IL-17) production in CD4 T cells stimulated by IL-15 exhibiting an IC50 of 20 60 nM In vivo oral administration of Y-320 (0 3 3 mg/kg) reduces IL-17 mRNA expression and suppresses the progression of collagen-induced arthritis (CIA) in mice with additional efficacy observed in cynomolgus monkey CIA models Combination with anti-TNF- monoclonal antibody yields a synergistic effect Y-320 serves as a valuable tool for studying IL-17-mediated inflammatory pathways and for preclinical research in rheumatoid arthritis and related autoimmune diseases
Apexbio Technology LLC Y-320 288250-47-5 10mg
Y-320 (CAS 288250-47-5) is a phenylpyrazoleanilide small molecule immunomodulator that inhibits interleukin-17 (IL-17) production in CD4 T cells stimulated by IL-15 exhibiting an IC50 of 20 60 nM In vivo oral administration of Y-320 (0 3 3 mg/kg) reduces IL-17 mRNA expression and suppresses the progression of collagen-induced arthritis (CIA) in mice with additional efficacy observed in cynomolgus monkey CIA models Combination with anti-TNF- monoclonal antibody yields a synergistic effect Y-320 serves as a valuable tool for studying IL-17-mediated inflammatory pathways and for preclinical research in rheumatoid arthritis and related autoimmune diseases