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Apexbio Technology LLC Y-320 288250-47-5 10mg
Supplier: Apexbio Technology LLC B342510
Y-320 (CAS 288250-47-5) is a phenylpyrazoleanilide small molecule immunomodulator that inhibits interleukin-17 (IL-17) production in CD4 T cells stimulated by IL-15 exhibiting an IC50 of 20 60 nM In vivo oral administration of Y-320 (0 3 3 mg/kg) reduces IL-17 mRNA expression and suppresses the progression of collagen-induced arthritis (CIA) in mice with additional efficacy observed in cynomolgus monkey CIA models Combination with anti-TNF- monoclonal antibody yields a synergistic effect Y-320 serves as a valuable tool for studying IL-17-mediated inflammatory pathways and for preclinical research in rheumatoid arthritis and related autoimmune diseases
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