Alpha beta-unsaturated carbonyl compounds
Medchemexpress LLC hsa-miR-141-3p mimic 5nmol | 5nmol
hsa-miR-141-3p mimics are small chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity
![eMolecules 2253964-85-9 | 7-(2-Butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-8-[(3S)-3-piperidinylamino]-1H-purine-2,6-dione | Toronto Research Chemicals472.553 | C25H28N8O2CC#CCn1c(N[C@H]2CCCNC2)nc2n(C)c(=O)n(Cc3nc(C)c4ccccc4n3)c(=O)c12 | 100mg | 601591821](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502176959.JPG-250.jpg)
eMolecules 2253964-85-9 | 7-(2-Butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-8-[(3S)-3-piperidinylamino]-1H-purine-2,6-dione | Toronto Research Chemicals472.553 | C25H28N8O2CC#CCn1c(N[C@H]2CCCNC2)nc2n(C)c(=O)n(Cc3nc(C)c4ccccc4n3)c(=O)c12 | 100mg | 601591821
7-(2-Butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-8-[(3S)-3-piperidinylamino]-1H-purine-2,6-dione | Toronto Research Chemicals | 2253964-85-9472.553 | C25H28N8O2CC#CCn1c(N[C@H]2CCCNC2)nc2n(C)c(=O)n(Cc3nc(C)c4ccccc4n3)c(=O)c12 | 100mg | 601591821
Medchemexpress LLC LIT-927 | 2172879-52-4 | 99.9% | 328.75 | 10 MG
LIT-927 is a locally and orally active CXCL12 neutraligand with an anti-inflammatory effect, exhibiting a Ki of 267 nM for CXCL12 binding to its specific receptor CXCR4.
- Locally active
- Orally active
- CXCL12 neutraligand
- Anti-inflammatory effect
- Exhibits a Ki of 267 nM for CXCL12 binding to its specific receptor CXCR4
Medchemexpress LLC SP-141 | 1253491-42-7 | 98.9% | 324.38 | 25 MG
SP-141 is a specific inhibitor of MDM2. It promotes MDM2 auto-ubiquitination and degradation. This compound may be used for the research of pancreatic cancer and breast cancer cells.
- Specific inhibitor of MDM2.
- Promotes MDM2 auto-ubiquitination and degradation.
- Potential for research in pancreatic cancer and breast cancer cells.
- Inhibits human pancreatic cancer cell growth with IC50 values of less than 0.5 μM in a p53-independent manner.
- Shows selective cytotoxicity for cancer cells.
- Induces MDM2 auto-ubiquitination and proteasomal degradation.
- Suppresses pancreatic tumor growth in both xenograft and orthotopic mouse models.
- Reduced tumor volume by 75% in a pancreatic xenograft model without significant differences in body weight in one study.
Pfaltz & Bauer 2 4 7 9-Tetramethyl-5-decyne-4 100G | 126-86-3
2 4 7 9-Tetramethyl-5-decyne-4 100G | 126-86-3
eMolecules 123-73-9 | Crotonaldehyde | Oakwood Chemical | MFCD00007003 | 70.091 | C4H6O | 95.000 | C\C=C\C=O | 25g | 536985190
Crotonaldehyde | Oakwood Chemical | 123-73-9 | MFCD00007003 | 70.091 | C4H6O | 95.000 | C\C=C\C=O | 25g | 536985190
Medchemexpress LLC NG-497 | 2598242-66-9 | 99.07% | 315.36 | 1 ML
NG-497 is a selective human adipose triglyceride lipase (ATGL) inhibitor that targets the enzymatically active patatin-like domain of human ATGL. It has potential value for tumor research. NG-497 selectively inactivates human and nonhuman primate ATGL but not structurally and functionally related lipid hydrolases, and abolishes human adipocytes in a dose-dependent and reversible manner lipolysis. NG-497 (40 μM, 80 min) reduces lipolysis-dependent respiration in HepG2 cells without impairing mitochondrial function through off-target effects.
- Selective human ATGL inhibitor
- Targets enzymatically active patatin-like domain
- Potential for tumor research
- Selectively inactivates human and nonhuman primate ATGL
- Abolishes human adipocytes in a dose-dependent and reversible manner lipolysis