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Cayman Chemical 1D-ArabInofurnosyluracIl 25g
An adenosine receptor agonist binds selectively to A1 over A2A and A3 receptors (Kis 0 83 2300 and 42 nM respectively for the human receptors expressed in CHO cells decreases heart rate in isolated rat atria (EC50 8 2 nM) but does not affect vasodilation in bovine coronary arteries inhibits isoniazid- and pentylenetetrazole-induced convulsions in mice at 8 3 mol/kg
Cayman Chemical 1D-ArabInofurnosyluracIl 5g
A selective inhibitor of human FLAP (IC50 2 9 nM) selective for FLAP over 5- 12- and 15-lipoxygenase LTA4 hydrolase LTC4 synthase COX-1 and COX-2 (IC50s 10 Um for all) inhibits production of LTB4 induced by the calcium ionophore A23187 in isolated whole blood from human rat and mouse (IC50s 436 223 and 148 nM respectively) decreases increases in the levels of CysLT and LTB4 induced by lung instillation of A23187 in the BALF of rats at 1 or 3 mg/kg reduces increases in the levels of CysLT LTB4 MPO and plasma protein extravasation in a mouse model of peritonitis induced by zymosan at 3 mg/kg
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