Incubator Accessories
Diagnostic Biosystems GLYCOPHORIN C Glycophorin C
This antibody is specific to β sialoglycophorin also known as glycophorin C. Glycophorin C is found on the human erythrocyte membrane and is one of four sialic acid-rich polypeptides.
Diagnostic Biosystems INSM1 A-8 INSM1 (A-8)
INSM1 (insulinoma-associated protein 1), also known as zinc-finger protein IA-1, is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic tissues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but it can be found highly expressed in neuroendocrine tumors. INSM1 contains five Cys2-His2-type zinc-finger DNA binding domains and a prohormone domain. INSM1 acts as a transcriptional repressor of the Neuro D promoter and recruits cyclin D1 as a corepressor. It plays an importantrole in neuroendocrine development and isrequired for normal differentiation of pancreatic endocrine cells. Inhibition of INSM1 results in decreased formation of glucagon and Insulin positive cells. The gene encoding INSM1 is directly regulated by Neurogenin 3 which binds chromatin in the INSM1 promoter region and induces transcription.
Diagnostic Biosystems HEPATOCYTE Hepatocyte Specific Antigen (OCH1E5)
Hepatoblastoma is the most common primary tumor of the liver in children. The use of specific hepatocyte markers and also of α fetoprotein or carcinoembryonic antigen are useful for the identification of normal and malignant fetal hepatocytes. This antibody recognizes an uncharacterized antigen present in both adults and fetal normal hepatocytes to produce a distinct granular cytoplasmic staining. This antibody stains majority of hepatocellular carcinomas.
Diagnostic Biosystems ALPHA-1-ANTITRYPSIN Alpha (α )-1-Antitrypsin
The antibody isspecific against human α-1-antitrypsin. This antibody stains macrophages in human tissues and does not stain any other cell type.
Diagnostic Biosystems UNOVUE MOUSE Mouse/Rabbit UnoVue™ HRP/DAB Detection System
The Mouse/Rabbit UnoVue™ HRP/DAB Detection System is a non-biotin, one-step detection system suitable for demonstrating antigens in formalin-fixed paraffin-embedded tissues and cryostat sections. The UnoVue Detection System may also be used with blood smears, cytosmears, and cell preparations. The UnoVue detector kits have been developed by directly labeling anti-mouse and anti-rabbit immunoglobulins with enzymes using a proprietary tandem hyper-labelling technology. This ensures consistent and reproducible immunodetection of mouse and rabbit antibodies with a single reagent. Nuclear, cytoplasmic and membrane antigens in different types of tissues can be detected readily. The single step UnoVue Detection System enables faster staining procedures than traditional two-step methods using biotin and avidin/streptavidin conjugates, avidin/streptavidin conjugates, with significantly lower background.
Diagnostic Biosystems RENAL CELL CARCINOMA Renal Cell Carcinoma (gp200)
This antibody recognizes a 200 kD glycoprotein (gp200) localized in the brush border of the proximal renal tebules and the luminal surface of Bowman’s capsule. gp200 was expressed by 93% of primary and 84% of metastatic renal carcinomas. Gp200 glycoprotein is also localized in the breast lobules and ducts, parathyroid glands and epididymis.
Diagnostic Biosystems NAPSIN A Napsin A
Napsin is found in two isoforms, A and B, with highly homologous gene sequences. Napsin A has a molecular weight of 35.0 kDa and is also known as TA02. Napsin A is an aspartic proteinase which is expressed in the lung and involved in processing surfactant protein B (SP-B). It is also expressed in the kidney. This antibody may be a useful tool as a tumor marker for primary lung adenocarcinoma. Napsin expression correlates with the differentiation grade of lung adenocarcinoma.
Diagnostic Biosystems PICRO SIRIUS RED STAIN KIT Picro Sirius Red Stain Kit
The Picro-Sirius Red Stain Kit (For Collagen) is intended for use in the histological visualization of collagen I and III fibers in addition to muscle in tissue sections.
Diagnostic Biosystems OCT 3/4 OCT-3/4 (OCT4/6847R)
OCT-3/4 (also known as POU5F1) is a transcription factor that has been recognized as fundamental in the maintenance of pluripotency in embryonic stem cells and primordial germ cells. It has been proposed as a useful marker for germ cell tumors (GCT) that exhibit features of pluripotentiality (seminoma/dysgerminoma, germinoma and embryonal carcinoma. OCT-3/4 immunostaining has been shown to be sensitive and specific for GCT, whether in primary gonadal or extragonadal sites or in metastatic lesions.
Diagnostic Biosystems IGM-FITC IgM-FITC
This antibody reacts with the Mu chain of human IgM. Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins. This antibody is well suited for tissue section staining but may also be used for other applications.
Diagnostic Biosystems SMOOTH MUSCLE MYOSIN Smooth Muscle Myosin (SMMS-1)
Smooth muscle myosin heavy chain (SM-MHC) is a cytoplasmic structural protein which is a major component of the contractile apparatus in smooth muscle cells. Expression of smooth muscle myosin is developmentally regulated, appearing early in smooth muscle development, and is specific for smooth muscle development. Two isoforms of smooth muscle myosin heavy chain have been identified, designated MHC-1 and MHC-2, they are differentially expressed depending on the functional activity of the muscle.\nThe antibody may be useful for the study of breast tumors as the presence of an intact layer of myoepithelial cells is an important feature, which may distinguish benign breast lesions and carcinoma in situ from invasive tumors
Diagnostic Biosystems MOC-31 MOC-31
MOC-31 antibody recognizes an epithelial-associated, glycoprotein located on the cell membrane surface and in the cytoplasm of virtually all epithelial cells. It is not present in most squamous epithelia, hepatocytes, renal proximal tubular cells, gastric parietal cells and myoepithelial cells. MOC31 may be used in a panel of antibodies as a negative marker for mesothelioma, or lung adenocarcinoma. Studies have shown that MOC-31 is useful in differentiating tumors of unknown origin in liver cancers and distinguishing cholangiocarcinoma from hepatocellular carcinomas
Diagnostic Biosystems STEINER Steiner
The Steiner Stain Kit (For Spirochetes) is designed for demonstrating Fungi, Helicobacter ylori, Legionella pneumophila, and Spirochete infected tissue. Kit may be used on formalin fixed, paraffin-embedded tissue.