Incubator Accessories
Diagnostic Biosystems CADHERIN 17 Cadherin 17
Cadherin 17 is exclusively expressed in the epithelial cells of embryonic and adult small intestine, colon, liver, and pancreatic ducts. It has been reported to be frequently expressed in adenocarcinomas arising in the gastrointestinal tract and pancreas. Owing to its restricted expression in these groups of tumors, cadherin 17 has proven to be a useful immunohistochemical marker for assisting in distinguishing these neoplasms from other malignancies with which they may be confused
Diagnostic Biosystems CYTOKERATIN 7 Cytokeratin 7 (LP1K)
Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratin 7 is expressed in epithelial cells of ovary, lung and breast. It is often used in conjunction with cytokeratin 20 and CDX-2 in distinguishing pulmonary, ovarian and breast carcinomas (CK7+) from most colon carcinomas (CK7-).
Diagnostic Biosystems MSH2 Mismatch Repair Protein 2, MSH2
Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
Diagnostic Biosystems UNOVUE MOUSE HRP DETECTION REA UnoVue™ Mouse HRP Detection Reagent
UnoVue Mouse HRP Detection Reagent is suitable for use with mouse all Ig antibodies, both monoclonal and polyclonal. The reagents can be used for manual staining or with automated staining instruments and are well suited for multiplex immunohistochemical staining assays.
Diagnostic Biosystems THROMBOSPONDIN Thrombospondin
This antibody is specific to 450 kDa (non-reduced) and 170 to 180 kD (reduced) form of thrombospondin. Thrombospondin is a protein from platelet α granules. It is secreted at sites of platelet activation and aggregation and is involved in the differentiation of leukocytes, fibroblasts, smooth muscle and endothelial cells.
Diagnostic Biosystems PEROXIDASE Universal HRP Immunostaining Kit (For Mouse and Rabbit Primary Antibodies)
This product is intended for qualitative immunohistochemistry with normal and neoplastic formalin-fixed, paraffin-embedded tissue sections, tobe viewed by light microscopy. Clinical interpretation of staining results should be accompanied by histological studies with proper controls. Patients’ clinical histories and other relevant diagnostic tests should be utilized by a qualified person (s) when evaluating and interpreting results. This kit is designed to label specific primary antibodies immunohistochemically on tissue sections. The immunohistochemical protocol defined in this brochure is just a guideline. Depending upon tissue fixation conditions, the primary antibody employed, and the user's experience, we encourage individual laboratory to optimize its own protocol. These reagents were tested and quality controlled using tissue sections, however, they can also be optimized for cell smears and cytospin preparations. Sufficient reagents are provided to run 50 to 100 tests.
Diagnostic Biosystems TNF-ALPHA TNF-Alpha (Tumor Necrosis Factor alpha)
This MAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-α (Tumor Necrosis Factor-alpha). Monomeric human TNF-α is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kDa and can be expressed as a free molecule, also TNF-α is generated as a precursor form called transmembrane TNF-α can be expressed as a cell surface type II polypeptide consisting of 233 amino acid residues molecular weight 26 kDa. TNF-α is an important cell-signaling component of the immune system. It is a protein secreted by LPS stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF-α is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Diagnostic Biosystems COPPER STAIN Copper Stain
The Copper Stain Kit (For Microwave) is intended for the demonstration of copper deposits in tissue sections.
Diagnostic Biosystems UNOVUE RABBIT AP DETECTION REA UnoVue™ Rabbit AP Detection Reagent
The UnoVue Rabbit AP Detection Reagent is suitable for use with rabbit antibodies, both monoclonal and polyclonal. The reagents can be used for manual staining or with automated staining instruments and are well suited for multiplex immunohistochemical staining assays.
Diagnostic Biosystems E-CADHERIN E-Cadherin (SPM471)
Recognizes a protein of 120-80kDa, identified as E-cadherin. Cadherins comprise a family of Ca2+-depedent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of tissue structure and morphogenesis. The c;assical cadherins, E-, N- and P-cadherin, consist of larg extracellular domains characterized by a series of five homologous NH2 terminal repeats. The relatively short intercellular domains interact with a variety of cytoplasmic proteins, such as β-catenin, to regulate cadherin function. E-cadherin plays an important role in epithelial cell adhesion. A decreased expression of E-cadherin is associated with metastatic potential and poor prognosis in breast cancer, prostate and esophageal cancer. In combination with p120 Catenin, it is useful for the differentiation between ductal (E-cadherin +) and lobular (E-cadherin -) breast carcinomas. It may also help in diagnosis of mesothelioma.
Diagnostic Biosystems CADHERIN 17 Cadherin 17
Cadherin 17 is exclusively expressed in the epithelial cells of embryonic and adult small intestine, colon, liver, and pancreatic ducts. It has been reported to be frequently expressed in adenocarcinomas arising in the gastrointestinal tract and pancreas. Owing to its restricted expression in these groups of tumors, cadherin 17 has proven to be a useful immunohistochemical marker for assisting in distinguishing these neoplasms from other malignancies with which they may be confused
Diagnostic Biosystems ALP LABEL Conjugated Enzyme Labels
Diagnostic BioSystems offers immunostaining detection systems based on streptavidin/biotin technology. We offer species-specific kits to etect antibodies raised in rabbits or mice and convenient broad spectrum kits to detect both. DBS detection systems are available in ready-touse formats, with the secondary antibody containing either goat anti-mouse and anti-rabbit IgG, goat anti-mouse IgG, or goat anti-rabbit IgG.