Microplate Lids
Cayman Chemical NItrIte Stndard 1ea
A GCGR GLP-1R and GIP receptor agonist induces cAMP accumulation in HEK293 cells expressing the human GCGR GLP-1R or GIP receptor (EC50s 5.79 0.775 and 0.0643 nM respectively) decreases plasma glucose levels in an intraperitoneal glucose tolerance test in mice from 0.1-30 nmol/kg decreases body weight calorie intake fat mass and lean mass in a mouse model of diet-induced obesity acute administration delays gastric emptying and chronic administration for 10 days decreases food intake and body weight in mice
Cayman Chemical ThIoglycerol Stndard 0.1mL
A disulfide bond-containing ionizable cationic lipid has been used in the generation of LNPs for plasmid delivery in vitro and in vivo LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP increase RRSP levels and decrease Ras levels in and reduce the viability of HeLa cancer cells LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart liver spleen lungs and kidneys as well as decrease tumor volume without reducing body weight in an HCT116 colorectal cancer mouse xenograft model
Alkali Scientific SmartWasher™ 96 Microplate Washer (MW9600)
The Alkali Scientific SmartWasher™ 96 Microplate Washer (MW9600) automates the process of ELISA plate washing so assays can be prepared quickly, accurately, and with confidence for absorbance reading. It’s the perfect companion to our popular SmartReader™ 96 microplate reader. Precision control of aspiration needle position– Accurate to 0.1mm– Minimal residual liquid, ≤1μl/well Auto rinse function eliminates cross contamination Up to 100 wash protocols can be customized and stored Liquid level sensors in wash and waste bottles Wash protocols can be transferred via flash drive
Cayman Chemical CyclIc GMP ELISA Stndard 1ea
An ionizable cationic lipidoid has been used in the generation of LNPs LNPs containing AA-T3A-C12 and encapsulating Hsp47 siRNA reduce the expression of Hsp47 in activated NIH3T3 mouse liver fibroblasts and primary mouse hepatic stellate cells LNPs containing AA-T3A-C12 and encapsulating Hsp47 siRNA reduce CCl4-induced liver fibrosis in mice
Cayman Chemical CyclIc AMP ELISA Stndard 1ea
An ionizable cationic lipidoid has been used in the generation of LNPs LNPs containing AA-T3A-C12 and encapsulating Hsp47 siRNA reduce the expression of Hsp47 in activated NIH3T3 mouse liver fibroblasts and primary mouse hepatic stellate cells LNPs containing AA-T3A-C12 and encapsulating Hsp47 siRNA reduce CCl4-induced liver fibrosis in mice
Cayman Chemical 96-Wel Cover Sheet 5ea
A multi-kinase inhibitor selectively inhibits MET VEGFR2 Axl and Mer (IC50s 3 15 5.8 and 0.6 nM respectively) over serine/threonine kinases for which it has no activity but does inhibit 28 additional RTKs (IC50s 3-54 nM) and additional kinases by greater than 70 at 1 UM inhibits the proliferation of SNU-5 cells (IC50 98.9 nM) and HUVECs (IC50 10.4 nM) reduces tumor volume and intratumoral MET phosphorylation in NCI H441 and SNU-5 mouse xenograft models at 3 and 10 mg/kg increases the number of peripheral B cells and CD4 T cells and decreases the number of peripheral myeloid cells in an MC-38 syngeneic mouse model of colon carcinoma at 30 mg/kg
Cayman Chemical LeukotrIen C4 EIA Stndard 1ea
An antagonist of NR2B subunit-containing NMDA receptors (Ki 72 nM) selective for NR2B subunit-containing NMDA receptors over those containing NR2A subunits (IC50s 47 and 10000 nM respectively) reduces carrageenan-induced hyperalgesia in rats (ED50 5.5 mg/kg) reduces dopaminergic neuron loss in the rat substantia nigra pars compacta and improves measures of ipsilateral curling ipsilateral head positioning and beam walking in a rat model of 6-OHDA-induced Parkinsons disease at 10 mg/kg
Cayman Chemical tetrnor-PGDM ELISA Stndard 1ea
A cationic lipid has been used for transfection of DNA RNA and other negatively charged molecules into eukaryotic cells has been used in the composition of small unilamellar liposomes formulated as gene delivery vectors for gene therapy
Cayman Chemical MorphIn ELISA Stndard 1ea
An internal standard for the quantification of ADB-5Br-BUTINACA by GC- or LC-MS intended for research and forensic applications