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A synthetic intermediate has been used as an intermediate in the synthesis of semaglutide as well as a lipid side chain to increase the proteolysis-resistance of insulin derivatives for use in vivo
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A triterpenoid with diverse biological activities inhibits ACE (IC50 734 UM) cytotoxic to HepG2 HeLa and Caco-2 cancer cells (IC50s 0.14 0.18 and 0.26 mg/ml respectively) inhibits LPS-induced NO production in BV-2 microglia (IC50 13.77 UM)
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A phospholipid-porphyrin conjugate LNPs containing 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC and encapsulating FAM-labeled siRNA increase cytosolic siRNA levels 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC-stabilized nanoemulsions loaded with paclitaxel and combined with laser irradiation reduce tumor growth and increase survival in a KB squamous cell carcinoma mouse xenograft model
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An EP1 receptor antagonist (Kis 0.6 and 1.7 nM for human and mouse receptors respectively expressed in CHO cells) is selective for EP1 over EP2 EP3 and EP4 (Kis 1000 67 and 1000 nM respectively for mouse receptors expressed in CHO cells) inhibits PGE2-induced increases in intracellular calcium concentrations in cells expressing human or mouse EP1 (EC50s 50 and 210 nM respectively) reduces the incidence of squamous cell carcinoma and severe dysplasia induced by 4-nitroquinoline 1-oxide in a rat model of tongue carcinogenesis at 400 and 800 ppm in the diet
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A cationic lipid has been used for transfection of DNA RNA and other negatively charged molecules into eukaryotic cells has been used in the composition of small unilamellar liposomes formulated as gene delivery vectors for gene therapy
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