A stearoyl-CoA desaturase inhibitor (IC50s 3 3 and 1 nM for rat mouse and human SCD1 respectively) selective for SCD1 over 5- and 6-desaturases (IC50s 100000 nM) reduces the hepatic but not Harderian gland ratio of oleic acid to stearic acid and blood glucose levels in a mouse model of high-fat diet-induced obesity from 20-60 mg/kg inhibits HCV replication in LucNeo2 cells (IC50 39.8 nM)