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An antiparasitic agent reduces the proliferation of T. brucei (IC50 63.1 nM) but not T. cruzi L. infantum P. falciparum or human MRC-5 fibroblasts (IC50s >6000 nM for all) reduces peripheral blood parasite levels below detection limits and increases survival in a mouse model of T. brucei infection at 50 mg/kg twice per day
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
An EP1 receptor antagonist (Kis 0.6 and 1.7 nM for human and mouse receptors respectively expressed in CHO cells) is selective for EP1 over EP2 EP3 and EP4 (Kis 1000 67 and 1000 nM respectively for mouse receptors expressed in CHO cells) inhibits PGE2-induced increases in intracellular calcium concentrations in cells expressing human or mouse EP1 (EC50s 50 and 210 nM respectively) reduces the incidence of squamous cell carcinoma and severe dysplasia induced by 4-nitroquinoline 1-oxide in a rat model of tongue carcinogenesis at 400 and 800 ppm in the diet
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A multi-kinase inhibitor inhibits FLT3 CSF1R c-Kit FGFR1 FGFR3 VEGFR1 -2 and -3 PDFGRa and PDGFRB (IC50s 1 36 2 8 9 10 13 8 27 and 210 nM respectively) inhibits the proliferation of human multiple myeloma cell lines expressing mutant but not wild-type FGFR3 (IC50s 90-550 and >2500 nM respectively) decreases FGF-induced ERK1/2 phosphorylation and induces apoptosis in patient-derived multiple myeloma cells at 500 nM inhibits bFGF-induced angiogenesis in a Matrigel™ plUG assay in mice at 3-300 mg/kg for 8 days reduces tumor growth in KM12L4A DU145 and MV4-11 mouse xenograft models (ED50s 17 23 and 3 mg/kg per day respectively)
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
A phospholipid-porphyrin conjugate LNPs containing 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC and encapsulating FAM-labeled siRNA increase cytosolic siRNA levels 1-palmitoyl-2-pyropheophorbide a-sn-glycero-3-PC-stabilized nanoemulsions loaded with paclitaxel and combined with laser irradiation reduce tumor growth and increase survival in a KB squamous cell carcinoma mouse xenograft model
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Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
Sealing Mats are manufactured of durable, pierceable silicone. Designed to fit Deep Well Plates and preserve contents and are suitable for heat sealing. Sealing Mats can be rewashed and reused, but autoclaving is not recommended.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More