ELISA Substrates and Reagents
ABclonal Technology Decorin Rabbit pAb
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients.
ABclonal Technology Phospho-IRE1-S724 Rabbit pAb
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
ABclonal Technology DDR2 Rabbit pAb
This gene encodes a member of the discoidin domain receptor subclass of the receptor tyrosine kinase (RTKs) protein family. RTKs play a key role in the communication of cells with their microenvironment. The encoded protein is a collagen-induced receptor that activates signal transduction pathways involved in cell adhesion, proliferation, and extracellular matrix remodeling. This protein is expressed in numerous cell types and may alos be involved in wound repair and regulate tumor growth and invasiveness. Mutations in this gene are the cause of short limb-hand type spondylometaepiphyseal dysplasia.
Cayman Chemical 11-keto Testosterone ELISA Antiserum, 100 dtn
11-keto Testosterone ELISA Antiserum, 100 dtn
ABclonal Technology Phospho-HSP27/HSPB1-S15 Rabbit pAb
This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.
ABclonal Technology pJNK1/2/3-T183/Y185/T221/Y223
The protein encoded by this gene is a member of the MAP kinase family MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation differentiation transcription regulation and development This kinase is activated by various cell stimuli and targets specific transcription factors and thus mediates immediate-early gene expression in response to cell stimuli The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis This kinase is also involved in UV radiation induced apoptosis which is thought to be related to cytochrom c-mediated cell death pathway Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation apoptosis and differentiation Several alternatively spliced transcript variants encoding distinct isoforms have been reported [provided by RefSeq Apr 2016]
American Research Products Inc Human Phosphotyrosine Insulin R PharmaGenie ELISA Kit
Human Phosphotyrosine Insulin R PharmaGenie ELISA Kit
ABclonal Technology Phospho-SRC Family-Y416 Rabbit pAb
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
Sino Biological Recombinant Human BAFF/BLyS/TNFSF13B Protein (Trimer, His & AVI Tag), Avi-tag Biotinylated, MALS-verified
A DNA sequence encoding the Human TNFSF13B (NP_006564.1) (Ala134-Leu285) was expressed with a N-terminal polyhistidine tag followed by an AVI tag.The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. This construct has a trimer design.