Protein Molecular Weight Markers
![ABclonal Technology [KO Validated] ITCH Rabbit mAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000134926.jpg-250.jpg)
ABclonal Technology [KO Validated] ITCH Rabbit mAb
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ABclonal Technology SCN3B Rabbit pAb
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified.
ABclonal Technology KIR3DL3 Rabbit pAb
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed on natural killer cells and some T cells. Encoded by polymorphic and homologous genes clustered at chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC), KIR gene content varies among haplotypes, though framework genes like KIR3DL3, KIR3DP1, KIR3DL4, and KIR3DL2 are always present. KIRs are classified by the number of extracellular domains (2D or 3D) and cytoplasmic tail length. Long-tailed KIRs deliver inhibitory signals via ITIMs, while short-tailed KIRs lack ITIMs and activate signals through TYRO binding protein. Many KIRs recognize subsets of HLA class I molecules, playing key roles in immune regulation. This gene is one of the universally present framework loci.
ABclonal Technology FGF4 Rabbit pAb
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.
ABclonal Technology CISD2 Rabbit pAb
The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2.
ABclonal Technology GPR82 Rabbit pAb
The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.
ABclonal Technology CYTH1 Rabbit pAb
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants.
ABclonal Technology SLC35A1 Rabbit pAb
The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology DAPK3 Rabbit pAb
Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis.
S2 Media 15x100mm Chameleon™ COLOREX™ COL-APSE (RUO), 10/pack
Chameleon™ COLOREX™ COL-APSE is a selective and differential, chromogenic culture medium used for the qualitative direct detection of gastrointestinal colonization with colistin-resistant gram-negative bacteria (COL-R) . Test specimens include rectal swabs, perineal swabs, and stools. For Research Use Only (RUO). Not for use in diagnostic procedures unless Laboratory Developed Test (LDT) validation with the product has been completed. Further identification, susceptibility testing, and epidemiological typing should be performed on suspect colonies.• Product meets CLSI performance criteria.• Chameleon™ COLOREX™ COL-APSE should be used by trained professionals within a laboratory setting. • For in vitro diagnostic (IVD) use.• Product is not intended for use in the diagnosis or treatment of disease or other human conditions.
ABclonal Technology MYH4 Rabbit pAb
Enables double-stranded RNA binding activity. Involved in muscle contraction. Located in myofibril.
ABclonal Technology NGDN Rabbit pAb
Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).
ABclonal Technology PPL Rabbit pAb
The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling.
ABclonal Technology Raptor Rabbit pAb
This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.
ABclonal Technology RABL3 Rabbit pAb
Predicted to enable GTP binding activity, GTPase activity, and protein homodimerization activity. Involved in regulation of Ras protein signal transduction and regulation of protein lipidation. Predicted to be active in endomembrane system. Implicated in pancreatic cancer.