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ABclonal Technology KIR3DL3 Rabbit pAb
Supplier: ABclonal Technology A10064500UL
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed on natural killer cells and some T cells. Encoded by polymorphic and homologous genes clustered at chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC), KIR gene content varies among haplotypes, though framework genes like KIR3DL3, KIR3DP1, KIR3DL4, and KIR3DL2 are always present. KIRs are classified by the number of extracellular domains (2D or 3D) and cytoplasmic tail length. Long-tailed KIRs deliver inhibitory signals via ITIMs, while short-tailed KIRs lack ITIMs and activate signals through TYRO binding protein. Many KIRs recognize subsets of HLA class I molecules, playing key roles in immune regulation. This gene is one of the universally present framework loci.
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