Protein Molecular Weight Markers
Cayman Chemical VItelogenInsalmon Monclo 500uL
A selective brain-penetrable LRRK2 inhibitor (Ki 0.7 nM) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinsons disease mutation (IC50 3 nM in vivo)
ABclonal Technology TOP1MT Rabbit pAb
This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
![ABclonal Technology [KO Validated] CDKN2C/p18-INK4C Rabbit mAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000134929.jpg-250.jpg)
ABclonal Technology [KO Validated] CDKN2C/p18-INK4C Rabbit mAb
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.
ABclonal Technology CDK9 Rabbit pAb
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.
ABclonal Technology C9orf72 Rabbit pAb
The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5 exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms.
Biotium Primary Antibody Neurofilament H rRmdO-20 CF680R 1/EA
Neurofilament-H (rRmdO-20) is a recombinant mouse monoclonal antibody that recognizes Neurofilament-H This CF680R antibody conjugate has been validated in Immunofluorescence CF and reg dyes are Biotiums line of next-generation fluorescent dyes with advantages in brightness and photostability
Abcam 5-Aminofluorescein (Fluoresceinamine, isomer I), Fluorescence marker, 250MG
MW 347.3 Da, Purity >95%. Fluorescence marker. Selectively targets malignant glioma tissue in vivo when covalently linked to human serum albumin at a molar ratio of 1:1without bleaching nor penetrating into surrounding brain edema or necrotic tissue. Blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
Creative Biomart Recombinant Borrelia Burgdorferi (strain B31) OspA Antigen, His-tagged
Recombinant Borrelia Burgdorferi (strain B31) OspA produced in E. coli is a non-glycosylated, full-length polypeptide chain having a calculated molecular mass of 27 kDa.Borrelia OspA is expressed with
ABclonal Technology TOMM22 Rabbit mAb
The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondrion.
ABclonal Technology RPS20 Rabbit mAb
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two transcript variants encoding different isoforms have been identified for this gene.
ABclonal Technology SRSF1/SF2/ASF Rabbit pAb
This gene encodes a member of the arginine/serine-rich splicing factor protein family. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. There is a pseudogene of this gene on chromosome 13.
ABclonal Technology SPIRE2 Rabbit pAb
Predicted to enable actin binding activity. Involved in establishment of meiotic spindle localization, formin-nucleated actin cable assembly, and positive regulation of double-strand break repair. Predicted to be located in cytoskeleton, cytosol, and plasma membrane. Predicted to be active in cell cortex and cytoplasmic vesicle membrane. Predicted to colocalize with cleavage furrow.
ABclonal Technology YME1L1 Rabbit pAb
The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mitochondrial protein metabolism and could be involved in mitochondrial pathologies. Three transcript variants encoding different isoforms have been found for this gene.
![ABclonal Technology [KO Validated] ITCH Rabbit mAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000134926.jpg-250.jpg)
ABclonal Technology [KO Validated] ITCH Rabbit mAb
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
ABclonal Technology SCN3B Rabbit pAb
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified.