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Selleck Chemical LLC ARS-1323-E1856-25MG
ARS-1323 is the racemic mixture containing ARS-1620 and a potent inhibitor of mutant KRAS G12C It can be used in research for biochemical binding screens as companion imaging drugs (CID) for KRAS G12C
Medchemexpress LLC ARS-1323 | 1698024-73-5 | 430.84 | 1 ML
ARS-1323 is a KRAS G12C inhibitor that specifically binds to the cysteine residue on the mutant K-Ras protein. This action locks K-Ras in its GDP-bound conformation, effectively blocking its activation and subsequent downstream signaling pathways. It is utilized for investigating signal transduction mechanisms and the growth characteristics of tumor cells driven by K-Ras G12C.
- Specifically binds to the cysteine residue on mutant K-Ras protein
- Blocks K-Ras activation and downstream signaling pathways
- Used to investigate signal transduction mechanisms
- Used for studying growth characteristics of KRAS G12C-driven tumor cells
- High purity of 99.7%
- Available in solid and solution formulations
Selleck Chemical LLC ARS-853
ARS-853 is a selective covalent KRAS(G12C) inhibitor that inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation ARS-853 also induces apoptosis
TARGETMOL CHEMICALS INC ARS-1630 5MG
Also available in 1mg 10mg 25mg 50mg 100mg and bulk. Please contact Fisher for quotes. ARS-1630 is a mutant K-ras G12C inhibitor. It is a less active enantiomer of ARS-1620. purity: 97%
TARGETMOL CHEMICALS INC ARS-1323 5MG
Also available in 1mg 10mg 25mg 50mg 100mg 500mg and bulk. Please contact Fisher for quotes. ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor. purity: 98%
Medchemexpress LLC ARS-1630 | 1698055-86-5 | 430.84 | 25 MG
ARS-1630 is a novel inhibitor of mutant K-ras G12C, derived from patent WO 2015054572 A1. It is characterized as a less active enantiomer of ARS-1620. This compound targets mutant K-ras G12C, which is considered potentially druggable through allele-specific covalent targeting of Cys-12 near an inducible allosteric switch II pocket. This approach relies on the active cycling of KRAS G12C between its active-GTP and inactive-GDP conformations, as the accessibility of the switch II pocket is limited to the GDP-bound state.
- Specifically inhibits mutant K-ras G12C.
- It is a less active enantiomer of ARS-1620.
- Molecular weight: 430.84.
- Chemical formula: C21H17ClF2N4O2.
- Appears as a white to yellow solid.
Medchemexpress LLC ARS-1323 | 1698024-73-5 | 430.84 | 100 MG
ARS-1323 is a potent KRAS G12C inhibitor. It specifically binds to the cysteine residue on the mutant K-Ras protein, locking it in the GDP-bound conformation and effectively blocking K-Ras activation and downstream signaling pathways. This compound is valuable for investigating signal transduction mechanisms and growth characteristics of tumor cells driven by K-Ras G12C.
- KRAS G12C inhibitor
- Specifically binds to the cysteine residue on the mutant K-Ras protein
- Blocks K-Ras activation and downstream signaling pathways
- Useful for investigating signal transduction mechanisms
- Useful for studying growth characteristics of K-Ras G12C driven tumor cells
- Supplied as a white to off-white solid
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Replacment end plate with luer lock for Jorvet 10cc Hauptner syringe.
Med Vet International Jorvet Plunger Plate for 10cc Hauptner Syringe, J0031D12A
Replacement plunger plate for Jorvet 10cc Hauptner syringe.
Med Vet International Jorvet Metal Cover for 10cc Hauptner Syringe, J0031D14A
Replacement metal cover for Jorvet 10cc Hauptner syringe.
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