Spectrophotometry
Cayman Chemical Precelys EvolutIon Touch 1ea
An inhibitor of the cardiac late INa (IC50 0.88 UM in HEK293 cells expressing the a subunit of Nav1.5) selective for the cardiac late INa over a panel of 11 cardiac ion channels at 1 UM as well as Nav1.1-1.4 and Nav1.6-1.8 (IC50s ≥5 UM for all) reverses anemone toxin-II-induced activation of MAPD90 in isolated rabbit hearts (EC50 0.72 UM) inhibits S-T segment elevation in a rabbit model of cardiac ischemia-reperfusion injury induced by occlusion of the left anterior descending artery (EC50 0.19 UM) decreases the incidence of ventricular tachycardia-ventricular fibrillation and mortality in a rabbit model of ischemia-induced arrhythmia induced by left circumflex artery ligation
Cayman Chemical Cryolys EvolutIon EquIpped Fa
An internal standard for the quantification of tianeptine by GC- or LC-MS
Cayman Chemical NIcotInIc AcId 500g
An analytical reference standard categorized as an arylcyclohexylamine intended for research and forensic applications
Cayman Chemical Precelys EvolutIon 96Wel 1ea
A metabolite of taurolithocholic acid has been used to study bile acid transport in cellular models and to induce pancreatitis in mouse models of bile acid infusion pancreatitis
Cayman Chemical 4-amIno NIcotInIc AcId 25g
A histamine H1 receptor antagonist (apparent Kis 1 41 and 1 62 nM using guinea pig cerebellar and lung membranes respectively) and mast cell stabilizer inhibits IgE-induced histamine TNF-a and IL-10 secretion in human CBMCs at 0 1 g/ml inhibits histamine-induced cutaneous vascular permeability in rats and bronchoconstriction in anesthetized guinea pigs (ID50s 5 and 0 1 mg/kg respectively) inhibits dye leakage into the conjunctiva in a rat model of passive anaphylaxis reaction-induced vascular hyperpermeability of the conjunctiva (ID50 9 7 mg/kg p o ) topical administration reduces lid edema tearing and redness as well as the number of neutrophils and eosinophils in the lid fornix in a mouse model of atopic conjunctivitis
Cayman Chemical Precelys EvolutIon 15 mL 1ea
An internal standard for the quantification of docosanoic acid by GC- or LC-MS
Cayman Chemical 2 E 4 ZDecadIenoIc AcId et 50g
An internal standard for the quantification of bufuralol by GC- or LC-MS
Cayman Chemical LactosylcRamID nd GnglIos 1mL
An FXR agonist (EC50 193 nM in a reporter assay) selective for FXR over the glucocorticoid androgen mineralocorticoid and progesterone receptors in HEK293 cells overexpressing the human receptors (EC50s 10 UM for all in a radioligand binding assay) increases the interaction between FXR and SRC-1 (EC50 121 nM in a cell-free assay) reduces plasma triglyceride and total cholesterol levels in LDL receptor-null mice (ED50s 3 4 and 2 mg/kg respectively) decreases plasma LDL and increases HDL levels in ZDF rats at 3 10 and 30 mg/kg for nine days
Cayman Chemical 4-amIno NIcotInIc AcId 5g
A broad-spectrum tetracycline antibiotic that inhibits protein synthesis in both Gram-positive and Gram-negative bacteria
Cayman Chemical 2 E 4 ZDecadIenoIc ACD et 100g
A positive allosteric modulator of a4B2 subunit-containing nAChRs potentiates ACh-induced currents in HEK293 cells expressing human a4B2 subunit-containing nAChRs (EC50 4 M) potentiates ABT-594 analgesic efficacy in rat models of carrageenan-induced thermal hyperalgesia paw skin incision post-operative pain and monoiodoacetate-induced osteoarthritis reduces nicotine self-administration and reinstatement in rats at 3 5 mg/kg
Cayman Chemical trns-nd-19 10mg
A nucleoside analog with diverse biological activities is converted to cordycepin triphosphate which inhibits ATP-dependent DNA and RNA synthesis incorporates into DNA and RNA in SK-HEP-1 cells is active against B. subtilis at 0.1-1 mg/ml increases IL-10 secretion and mRNA expression in isolated human PBMCs at 24 Ug/ml increases survival of mice infected with C. albicans or C. krusei at 1 mg/kg per day
Cayman Chemical Precelys EvolutIon Metal 1ea
A positive allosteric modulator of mGluR4 potentiates glutamate responses in CHO cells expressing recombinant human mGluR4 (EC50 19.8 nM)