Hydroxybenzoic Acid Derivatives
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AdipoGen NAI-108
Chemical. CAS 1820892-86-1. Formula C94H127BrN26O27S5 A1, C94H127BrN26O26S5 A2. MW 2293.4 A1 R=OH2277.4 A2 R=H. Isolated from Actinoallomurus sp. Antibacterial class I lantibiotic. Brominated variant of NAI-107. Inhibits cell wall synthesis and consequently bacterial growth by forming a complex with lipid intermediate II Lipid II, a key intermediate in peptidoglycan biosynthesis. Efficiently interfers with late stages of cell wall biosynthesis leading to accumulation of the soluble peptidoglycan precursor UDP-N-acetylmuramic acid-pentapeptide UDP-MurNAc-pentapeptide in the cytoplasm. Slightly higher activity than NAI-107 against multidrug-resistant Gram-positive pathogens.
