Oligonucleotides
Sklar Instruments Needle Holder Sklar Microscopy Surgical 1/EA
Needle Holder Sklar Microscopy Surgical 1/EA
Abcam GSK503, EZH2 methyltransferase inhibitor, 5MG
MW 526.7 Da. Potent (IC₅₀ = nM; Ki = 3 nM) and specific EZH2 methyltransferase inhibitor. Selective against EZH1 (IC₅₀ = 633 nM). At least 4000-fold selective over a panel of 20 other human methyltransferases. Highly selective against a range of human histone deacetylases, GPCRs, kinases and ion channels. Reduces cellular H3K27me3 levels. Inhibits growth of diffuse large B-cell lymphoma cells. Inhinits melanoma growth and metastasis in mouse models.
The product is subject to the following: Abcam Restricted Use Statement
New England Biolabs, Inc. Monarch® Spin Collection Tubes - 100 tubes
Monarch Spin Collection Tubes are designed to be used with Monarch Spin Columns for collection of waste and other fractions during centrifugation steps in Monarch Spin Nucleic Acid Purification Kits.
- Compatible with all Monarch Spin Columns
- Designed and manufactured with less plastic than other leading suppliers
AdipoGen ODN 1826 (Type B) Endotoxin-free (sterile), 1 mg
MW: 6,383g/mol, Synonyms: CpG ODN TLR9 Agonist: B Type (species: rodent). Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in microbial DNA via the Toll-like receptor (TLR) 9 if the CpG ODN were free of additional immune stimulatory contaminants often present in synthetic commercial CpG ODN preparations designed for molecular biology applications (i.e. PCR). Given that high quality CpG ODNs were used, a close link has been established between the expression of TLR9 on certain immune cell subsets and the modulation of the immune system by CpG DNA.
AdipoGen ODN 2395 (Type C) Endotoxin-free (sterile), 3x1 mg
MW: 7,068g/mol, Synonyms: CpG ODN: C Type (species: human and rodent). Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in microbial DNA via the Toll-like receptor (TLR) 9 if the CpG ODN were free of additional immune stimulatory contaminants often present in synthetic commercial CpG ODN preparations designed for molecular biology applications (i.e. PCR). Given that high quality CpG ODNs were used, a close link has been established between the expression of TLR9 on certain immune cell subsets and the modulation of the immune system by CpG DNA.
New England Biolabs, Inc. Monarch® Mag Viral DNA/RNA Extraction Kit - 100 preps
The Monarch Mag Viral DNA/RNA Extraction Kit is designed for hands-free isolation of viral nucleic acid from saliva, respiratory-swab samples using automated processing and liquid handling systems. The kit features a magnetic bead-based method for extraction and purification and is compatible with automated instruments such as KingFisher, Agilent Bravo, and more, as well as manual workflows. The kit enables highly sensitive detection and amplification in qPCR/RT-qPCR, ddPCR applications and is compatible with other downstream applications such as sequencing/NGS. Carrier RNA is included as a co-precipitant in the workflow to enhance the recovery of low amounts of viral RNA.
- Designed for hands-free extraction of viral DNA and/or RNA
- Utilizes magnetic bead-based methods, supporting automated and manual workflows
- Developed for highly sensitive amplification, sequencing, and other downstream applications
New England Biolabs, Inc. WarmStart RTx Reverse Transcriptase (Glycerol-free) - 2000 units
WarmStart RTx Reverse Transcriptase (Glycerol-free) is formulated without glycerol to support lyophilization, incorporation into microfluidic devices, and enable quick adoption into automation workflows. WarmStart RTx Reverse Transcriptase is a unique in silico designed RNA-directed DNA polymerase coupled with a reversibly-bound aptamer that inhibits RTx activity below 40°C. This enzyme can synthesize a complementary DNA strand initiating from a primer using RNA (cDNA synthesis) or single-stranded DNA as a template. RTx is a robust enzyme for RNA detection in amplification reactions and is particularly well suited for use in LAMP (loop-mediated isothermal amplification). The WarmStart property enables high throughput applications, room temperature setup, and increases the consistency and specificity of amplification reactions. RTx contains intact RNase H activity.
Sklar Instruments Needle Holder Sklar Microscopy Surgical 1/EA
Needle Holder Sklar Microscopy Surgical 1/EA
Vector Biolabs codon optimized Cre (iCre) and GFP Adenovirus (Ad-GFP-2A-iCre)
Ready to use in vivo grade AAV and Adenovirus Ready to use in vivo grade AAV and Adenovirus pre synthesized DNA vector High titer viral vectors 1/EA
Vector Biolabs Cell division cycle 25C Adenovirus (Ad-Cdc25C)
Ready to use in vivo grade AAV and Adenovirus Ready to use in vivo grade AAV and Adenovirus pre synthesized DNA vector High titer viral vectors 1/EA
Abcam Heliquinomycin, Antibiotic agent, 250UG
MW 698.6 Da, Purity >80%. Antibiotic agent. DNA helicase inhibitor (IC₅₀ values are 4.3 and 2.5 μM for DNA helicase B and MCM4/6/7 helicase respectively). Inhibits DNA replication (IC₅₀ values are 1 - 4 μM). Weak topoisomerase I and II inhibitor. Inhibits DNA and RNA synthesis. Does not inhibit protein synthesis. Induces G2/M cell cycle arrest. Shows antibacterial effects. Inhibits cancer cell line growth (IC₅₀ values are 1.4 - 4 μM).
The product is subject to the following: Abcam Restricted Use Statement