Oligonucleotides
Abcam Heliquinomycin, Antibiotic agent, 250UG
MW 698.6 Da, Purity >80%. Antibiotic agent. DNA helicase inhibitor (IC₅₀ values are 4.3 and 2.5 μM for DNA helicase B and MCM4/6/7 helicase respectively). Inhibits DNA replication (IC₅₀ values are 1 - 4 μM). Weak topoisomerase I and II inhibitor. Inhibits DNA and RNA synthesis. Does not inhibit protein synthesis. Induces G2/M cell cycle arrest. Shows antibacterial effects. Inhibits cancer cell line growth (IC₅₀ values are 1.4 - 4 μM).
The product is subject to the following: Abcam Restricted Use Statement
Abcam Bendamustine hydrochloride, DNA alkylating agent, 10MG
MW 394.7 Da, Purity >99%. DNA alkylating agent. Causes DNA intrastrand and interstrand cross-links. Induces apoptotic gene expression. Anticancer, apoptotic agent in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Gemcitabine, Cytidine analog, 100MG
MW 263.2 Da, Purity >98%. Cytidine analog. Antimetabolite. Induces apoptosis. Blocks cytosine nucleotide conversion into the deoxy derivative and blocks incorporation of the thymidine nucleotide into the DNA strand. Shows antitumor effects in vivo. .
The product is subject to the following: Abcam Restricted Use Statement
Active Motif Human Positive Control Primer Set ACTB-2
Human Control qPCR Primer Sets were designed to serve as positive or negative ChIP controls when performing chromatin immunoprecipitation with human samples. Each primer set is a mixture of forward and reverse primers that have been validated for qPCR and endpoint PCR of ChIP samples from multiple human cell lines.
Abcam Procainamide hydrochloride, Sodium channel blocker, 10G
MW 271.79 g/mol, Purity >99%. Sodium channel blocker. Specific DNA methyltransferase 1 inhibitor (Ki = 7.2 μM). Antiarrhythmic in vivo. Limited ability to cross the blood-brain barrier.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology ABCA1 Rabbit mAb
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ABC proteins transport various molecules across extra- and intracellular membranes ABC genes are divided into seven distinct subfamilies (ABC1 MDR TAP MRP ALD OABP GCN20 White) This protein is a member of the ABC1 subfamily Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes With cholesterol as its substrate this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway Mutations in both alleles of this gene cause Tangier disease and familial high-density lipoprotein (HDL) deficiency
Invivogen ODN 2395 - TLR9 ligand, 5 mg
CpG ODNs are synthetic oligonucleotides that contain unmethylated CpG dinucleotides in particular sequence contexts (CpG motifs).
New England Biolabs, Inc. NEBNext Multiplex Oligos for Illumina (96 Unique Dual Index Primer Pairs Set 2) – 384 reactions
NEBNext Multiplex Oligos provide adaptors and primers to enable high yield multiplex Illumina library production. Unique Dual Index (UDI) primer pairs enable the identification and mitigation of the impacts of index hopping when using a patterened flow cell. The unique hairpin loop structure of the NEBNext Adaptor minimizes adaptor-dimer formation, and NEBNext index PCR primers enable index incorporation during library amplification. This kit includes 96 pre-mixed unique pairs of i5 and i7 index primers, packaged in a single-use 96-well plate with a pierceable foil seal. Additional NEBNext Multiplex Oligos products are available for different indexing strategies.
Apexbio Technology LLC EZ Cap™ Cre mRNA (5-moUTP) 1mg (1mg/mL)
EZ Cap Cre mRNA 5-moUTP encodes Cre recombinase a tyrosine recombinase enzyme that facilitates homologous DNA recombination between two specific loxP recognition sites It is designed to promote precise DNA recombination thereby enabling conditional gene modification in mammalian systems EZ Cap Cre mRNA 5-moUTP exerts its biological activity primarily through expression of Cre recombinase which catalyzes site-specific recombination at loxP sites This mRNA incorporates a Cap 1 structure and 5-methoxyuridine triphosphate (5-moUTP) modification to reduce innate immune responses and improve translational stability Based on these properties EZ Cap Cre mRNA 5-moUTP holds research potential in genome editing experiments conditional gene knockout studies and reporter gene activation in mammalian research models
ABclonal Technology Phospho-STING/TMEM173-S366
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy Alternate splicing results in multiple transcript variants