Oligonucleotides
Cayman Chemical ANTIBODY TAK-733 10mg
A MEK1 inhibitor (IC50 = 3.2 nM); inhibits ERK phosphorylation in vitro (EC50 = 1.9 nM); inhibits proliferation of A375 and COLO 205 cells (EC50s = 3.1 and 2.1 nM, respectively) and 14 cutaneous melanoma cell lines (IC50s = V600E mutations
ABclonal Technology RAG1 Rabbit pAb
The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.
Revvity Health Sciences Inc HTRF Sunitinib Red Ligand, 20 nmoles
HTRF Sunitinib Red Ligand, 20 nmoles
ABclonal Technology Phospho-GRIN2B-Y1474 Rabbit pAb
This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.
Genscript Corporation CD43 hFc Chimera Mouse
CD43 is a large transmembrane protein involved in T cell activation Previous studies of CD43-/- mice in viral models have demonstrated a role for CD43 in Th1/Th2 skewing activation of Foxp3 Treg and T cell apoptosis CD43 (leukosialin) is a large sialoglycoprotein abundantly expressed on the surface of most cells from the hematopoietic lineage CD43 is directly involved in the contact between cells participating in a series of events such as signaling adherence and host parasite interactions
Biotium SOX9 / SRY-box 9(SOX9/2287R), CF488A conjugate, 0.1mg/mL
The specificity of this monoclonal antibody to its intended target was validated by HuProt™ Array, containing more than 19, 000, full-length human proteins. Plays an important role in the normal skeletal development. May regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Nucleus (Potential). Campomelic dysplasia (CMD1) : Rare, often lethal, dominantly inherited, congenital osteo-chondrodysplasia, associated with male-to-female autosomal sex reversal in two-thirds of the affected karyotypic males. A disease of the newborn characterized by congenital bowing and angulation of long bones, unusually small scapulae, deformed pelvis and spine and a missing pair of ribs. Craniofacial defects such as cleft palate, micrognathia, flat face and hypertelorism are common. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and phot
Cayman Chemical N4TosylLargInIn methyl e 5g
A synthetic substrate of serine proteases, including thrombin, trypsin, chymotrypsin, and kallikreins; also binds to and inhibits anaphase-promoting complex, a ubiquitin ligase, in Xenopus egg extract
Biotium SOX9 / SRY-box 9 (PCRP-SOX9-1A2), Biotin conjugate, 0.1mg/mL
The specificity of this monoclonal antibody to its intended target was validated by HuProt™ Array, containing more than 19,000, full-length human proteins. Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are n
ABclonal Technology Phospho-PTEN-S380/T382/383 Rabbit pAb
This gene encodes a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase that functions as a tumor suppressor, frequently mutated in various cancers. The protein contains a tensin-like domain and a catalytic domain similar to dual specificity protein tyrosine phosphatases, but preferentially dephosphorylates phosphoinositide substrates. It regulates AKT/PKB signaling by decreasing phosphatidylinositol-3,4,5-trisphosphate levels. A non-canonical initiation site produces a longer isoform, potentially involved in regulating mitochondrial energy metabolism. A pseudogene exists on chromosome 9. Alternative splicing and multiple start codons generate different isoforms of the protein.
BIOHIPPO AAV-CAG-H2B-tdTomato-WPRE-hGH-polyA
Recombinant adeno associated virus expressing TDTOMATO H2B-tdTomato under the CAG promoter with WPRE and hGH polyA elements. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Medchemexpress LLC Zingibroside R1 | 80930-74-1 | 5 MG
Zingibroside R1 is a dammaranae-type triterpenoid saponin isolated from the rhizomes, taproots, and lateral roots of Panax japonicus C. A. Meyer. It exhibits anti-tumor effects, anti-angiogenic activity, and anti-HIV-1 activity. It also shows inhibitory effects on 2-deoxy-D-glucose (2-DG) uptake by EAT cells with an IC50 of 91.3 μM. This compound has a molecular weight of 794.97, a chemical formula of C42H66O14, and appears as a white to off-white solid.
- Isolated from Panax japonicus C. A. Meyer
- Exhibits anti-tumor effects
- Shows anti-angiogenic activity
- Possesses anti-HIV-1 activity
- Inhibits 2-deoxy-D-glucose (2-DG) uptake by EAT cells (IC50=91.3 μM)
- Molecular weight: 794.97
- Chemical formula: C42H66O14
- Appearance: white to off-white solid
- Purity: 99.47%
Meso Scale Discovery GAPDH Kit
The Meso Scale Discovery GAPDH Kit (K151PWD) is a 96-well plate assay kit for quantifying GAPDH protein in cell and tissue lysates The kit contains a 96-well plate coated with capture antibody detection antibody Read Buffer Sample Diluent and lyophilized GAPDH protein standard The electrochemiluminescent assay has a typical sensitivity of 1-2 pg/mL and a broad dynamic range up to 4 logs The kit can be used to normalize target protein levels or as a reporter gene assay It is suitable for cells and tissues including human mouse rat monkey canine porcine and rabbit
ABclonal Technology MCT4/SLC16A3 Rabbit pAb
Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1, MIM 600682) and MCT2 (SLC16A7, MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).
BIOHIPPO AAV-hSyn-Flex-EGFP-T2A-Synaptophysin-mRuby-WPREs
Recombinant adeno associated virus expressing EGFP Synaptophysin-mRuby under the hSyn promoter with WPRE and hGH polyA elements. The Cre and Flp logic configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.