Oligonucleotides
Cayman Chemical 1113 14dIhydro15keto Pro 100ug
A metabolite of PGD2; appears in plasma of normal males within 10 minutes of tritiated PGD2 infusion or inhalation
BIOHIPPO AAV-mCD68-Cre-WPRE-PA
Recombinant adeno associated virus expressing Cre under the mCD68 promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
ABclonal Technology MMP9 Rabbit pAb
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
Abcam UNC1999, EZH2 methyltransferase inhibitor, 25MG
MW 569.7 Da, Purity >98%. Potent, selective cell-permeable dual inhibitor of EZH2 and EZH1 methyltransferase inhibitor (IC₅₀ = 45 nM and 2 nM respectively) (Konze et al. ). Inhibits H3K27 methylation (IC₅₀ = 124 nM, MCF10A cells). Competitive with the cofactor SAM, and non-competitive with the peptide substrate. Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib in suppressing the proliferation of colon cancer cells (Katona et al.). It suppresses global H3K27 trimethylation/demethylation and inhibits the growth of mixed lineage leukemia (MLL)-rearranged leukemia cells ( Xu et al.). Orally bioavailable.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology IL6 Rabbit pAb
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2).
Meso Scale Discovery U-PLEX Human vWF ASYQP
The Meso Scale Discovery U-PLEX Human VWF Assay is an electrochemiluminescent immunoassay for quantifying von Willebrand Factor (VWF) in human serum plasma and cell culture supernatants It uses MSD s SULFO-TAG labels and multi-array technology with a detection limit of 0 03 ng/mL and quantification up to 100 ng/mL Requiring 50 L of sample the assay takes about 3 5 hours It aids in diagnosing von Willebrand disease and other VWF-related conditions The kit includes a 96-well plate detection antibody calibrators diluent and necessary reagents
SAPPHIRE NORTH AMERICA NaveniFlex Cell GR Atto647N
Detect proteins, protein-protein interactions, or protein modifications in cell samples. The assay is designed to be used with a goat and rabbit primary antibody pair. Detection with Atto647N fluorophore is included.
BIOHIPPO AAV-mDLX-Cre-WPRE-hGH-polyA
Recombinant adeno associated virus expressing Cre under the mDlx promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Cayman Chemical 1a 1b-dihomo Prostaglandin F2
A theoretical product of adrenic acid in the COX pathway; primarily produced in renal medulla where adrenic acid is selectively distributed
Med Vet International EXCISION/GEN/II/ANAL/SAC/KIT
The surgical excision of both anal sacs can be elected as a permanent solution to these reoccurring issues Overview of Product The Gen II product uses a safe and nontoxic polymer gel that is infused as soft gel into the empty anal sac The gel solidifies after 2-4 minutes in the anal sac This provides an easily discernible mass that can be dissected out fairly readily This reduces surgery time and the risk of leaving anal sac remnants Kit is a single complete unit 18g plastic blunt angled needle for easy insertion in to anal sac opening /duct Dual chambered cartridge of polymer with mixing tip -Gel solidifies 2-4 minutes upon application Capacity of 2 4cc is sufficient for larger patients Superb ergonomic design for small hands Simple turn and click of syringe hub opens gel pathway Includes directions for use Gen II Anal Sac Excision Kit 5/pk
AdipoGen cGAMP 2Na STING Ligand
Chemical. CAS 849214-04-6 free acid. Formula C20H24N10O13P2 . 2Na. MW 674.4 . 46.0. Synthetic. Potent STING ligand. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA. Binding to STING leads to activation of IRF3 IFN regulatory factor 3 and the induction of interferon-beta. First cyclic nucleotide in metazoa. Plays a role in bacterial chemotaxis and colonization.
Abcam 3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor.
This product is for research use only and not for diagnostic or therapeutic procedures. Customer is granted a limited, non-exclusive license for internal research and shall not attempt to reverse engineer.
3-Deazaneplanocin A hydrochloride (DZNep), Lysine methyltransferase EZH2 inhibitor.
Hach Company SC4500 Ctrl C1D2 Prog 5x mA Ou
SC4500 Controller-C1D2-Prognosys-5x mA Output-1 mA Input-24 VDC-without plugIncludes SC4500 Controller-Claros-enabled-with EU plug includes mounting hardware
INTACT GENOMICS INC igScript™ Glycerol-free Reverse Transcriptase 50,000 units (200 u/µl)
igScript™ Glycerol-free Reverse Transcriptase is a recombinant Moloney Murine Leukemia Virus (MMLV) reverse transcriptase with reduced RNase H activity. It is highly efficient at producing full-length cDNA from long RNA templates. igScript RT is an RNA-directed DNA polymerase which lacks 3´ → 5´ exonuclease activity and is capable of producing cDNA from as little as 50 pg of total RNA for real-time RT-PCR analysis and other applications.Benefits: Recombinant MMLV reverse transcriptase with greatly reduced RNase H activity. Active at temperatures up to 55°C. Highly efficient at producing full-length cDNA from as little as 50 pg of total RNA.Product Includes: igScript™ Glycerol-free Reverse Transcriptase 10x igScript™ RT Reaction BufferStorage Temperature: –80 °C
Enzo Life Sciences Oligomycin A (25mg). CAS: 579-13-5
Inhibits mitochondrial ATPases (F1F0). Stimulates lysosome acidification due to shunting of membrane potential. Induces apoptosis in a variety of cell types. Induces autophagy in the IPLB-LdFB insect cell line. Purity: ≥97% (HPLC, TLC). Solubility: Soluble in DMSO (300mg/ml), 100% ethanol (200mg/ml) or acetone (800mg/ml). Long Term Storage: -20°C.