Oligonucleotides
Medchemexpress LLC N-(4-butylphenyl)-5-nitrofuran-2-carboxamide | 346691-38-1 | MFCD00784211 | 99.7% | 288.30 | C15H16N2O4 | 5 MG
STING-IN-2 is a potent, covalent inhibitor of the stimulator of interferon genes (STING) protein used as a research tool to study STING-mediated signaling, innate immune responses, and autoinflammatory disease mechanisms. It inhibits both human and mouse STING and is supplied in small milligram quantities for in vitro and preclinical research.
- Potent covalent inhibition of STING.
- Active against human and mouse STING.
- Useful for studying STING-mediated innate immune signaling.
- Suitable for in vitro and preclinical research applications.
- Characterized and high-purity material for research use.
![ABclonal Technology [KO Validated] Bax Rabbit pAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000138792.jpg-250.jpg)
ABclonal Technology [KO Validated] Bax Rabbit pAb
BAX (BCL2 Associated X) is a pro-apoptotic member of the BCL2 protein family, crucial in regulating apoptosis. It contains four Bcl-2 homology (BH1–BH4) domains and a C-terminal transmembrane domain. In healthy cells, BAX remains in the cytoplasm via interaction with anti-apoptotic proteins like BCL2L1 (Bcl-xL). Upon apoptotic stimuli, BAX undergoes a conformational change and translocates to the outer mitochondrial membrane, where it promotes apoptosis through two main mechanisms: interacting with the voltage-dependent anion channel (VDAC) to release cytochrome c, or forming oligomeric pores that permeabilize the membrane. Released cytochrome c activates caspase-3, triggering cell death. BAX is also a direct transcriptional target of p53 and plays a role in p53-mediated apoptosis, with p53 both regulating its expression and interacting with BAX to enhance its activity.
ABclonal Technology E.coli DNA Ligase
E. coli DNA Ligase catalyzes the formation of a phosphodiester bond between the 5-phosphate and the 3-hydroxyl of two adjacent DNA strands in duplex DNA with cohesive ends. It is not appreciably active on blunt-ended substrates. E. coli DNA Ligase uses NAD as a cofactor and can be heat-inactivated. E. coli DNA Ligase is active at a range of temperatures (4°C - 37°C).
ABclonal Technology Rev-erb beta/NR1D2 Rabbit mAb
This gene encodes a member of the nuclear hormone receptor family specifically the NR1 subfamily of receptors The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism Alternatively spliced transcript variants have been described
Active Motif DNA Library Prep Kit, High Sensitivity, Compatible with Illumina Platforms, Kit
The Active Motif DNA Library Prep Kit is a high-sensitivity solution designed for preparing next-generation sequencing (NGS) libraries from double-stranded DNA for Illumina platforms. It ensures accurate and reproducible results, even with low input material, by using molecular identifiers to minimize PCR duplicates. This kit supports various applications, including genomic DNA-seq, and is compatible with multiple Illumina platforms, offering flexibility and enhanced unique alignment rates.
ABclonal Technology HES1 Rabbit pAb
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Cayman Chemical Bax Chnl Blocker 10mg
A Bax inhibitor; binds to Bax in a cell-free assay (Kd = 15 µM); inhibits tBID-induced Bax-mediated membrane permeabilization in a liposomal release assay (IC50 = 3.3 µM); inhibits TNF-α- and cycloheximide-induced apoptosis in MEFs (IC50 = 1.8 µM); inhibits BTSA1-induced cell death in OCI-AML-3 cells
New England Biolabs, Inc. Bst 2.0 WarmStart DNA Polymerase (Glycerol-free) - 8000 units
Bst 2.0 WarmStart DNA Polymerase (Glycerol-free) is formulated without glycerol to support lyophilization, incorporation into microfluidic devices, and enable quick adoption into automation workflows. Bst 2.0 WarmStart DNA Polymerase is an in silico designed homologue of Bacillus stearothermophilus DNA Polymerase I, Large Fragment (Bst DNA Polymerase, Large Fragment) with a reversibly-bound aptamer, which inhibits polymerase activity at temperatures below 45°C. At temperatures above 45°C, the aptamer rapidly releases from the enzyme with no special activation step needed to activate the polymerase. Bst 2.0 WarmStart DNA Polymerase contains 5' to 3' DNA polymerase activity and strong strand-displacement activity but lacks 5' to 3' exonuclease activity. Bst 2.0 WarmStart DNA Polymerase displays improved amplification speed, yield, salt tolerance, and thermostability compared to wild-type Bst DNA Polymerase, Large Fragment.
Abcam EI1, EZH2 inhibitor, 100MG
MW 390.5 Da. Potent (IC₅₀ = 15 nM for wild-type enzyme; 13 nM for Y641F mutant enzyme) EZH2 inhibitor. Selective versus EZH1 (142-fold). Highly selective (>10,000-fold) against a panel of 10 other human methyltransferases. Inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression in diffuse large B-cell lymphoma cells (DLBLC). Selectively inhibits growth and promotes cell cycle arrest and apoptosis of DLBLC cells with Y641 EZH2 mutations.
The product is subject to the following: Abcam Restricted Use Statement
Cell Systems Corporation Cultureboost-R is a human recombinant growth factor that also acts as a supplement in Cell Systems Complete Classic Medium (4Z0-500-R) and Cell Systems Medium Minus Serum (4Z3-500-R).
CultureBoost-R™ is a human recombinant growth factor that also acts as a supplement in Cell Systems Complete Classic Medium (4Z0-500-R) and Cell Systems Medium Minus Serum (4Z3-500-R). It is available in a 10mL vial in various Cell Systems media kits and "The System" as well as for purchase separately. Our high-quality formula, containing human growth factors and porcine heparin, is suitable for caring for extremely fastidious cells. CultureBoosy-R offers these benefits for your cell culture: it enhances cell growth across various Cell Systems media formulations, stabilizes cell membranes after freezing or passage, and promotes efficient cell attachment, activation, and polarization. Large quantities? Contact your Fisher Scientific sales representative to discuss your bulk order needs. Research on a tight deadline? Available for next day delivery after the purchase order is received. Maximize your results! Try our Primary Human Cells and Passage Reagent Group (4Z0-800).
ABclonal Technology Non-pAct -CateninS33/S37/T41
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs) AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete Finally this protein binds to the product of the APC gene which is mutated in adenomatous polyposis of the colon Mutations in this gene are a cause of colorectal cancer (CRC) pilomatrixoma (PTR) medulloblastoma (MDB) and ovarian cancer Alternative splicing results in multiple transcript variants
New England Biolabs, Inc. RNase 4 - 12500 units
RNase 4 is a single-stranded RNA endonuclease that cleaves 3' of uridine in uridine-purine sequences (cut sites: U/A and U/G). RNase 4 allows more targeted digestion of substrate RNA material compared to single nucleotide specific RNases like T1 (cut site: after G), RNase U2 (cut sites: after A and G), or bovine pancreatic RNase A (cut sites: after C and U). RNase 4 endonuclease activity tolerates uridine base modifications such as pseudo-, N1-methyl-pseudo-, dihydro-, and 5-methoxy-uridine species. Due to the chemical mechanism of RNase 4 endonucleolytic cleavage, product oligonucleotides contain heterogenous 3' ends, where most species contain a linear 3'-phosphate or cyclic 2',3'-phosphate.