Oligonucleotides
Cayman Chemical TFF1 trefoil factor 1 or pS2
An alkaloid inhibits the growth of human A375 A431 A549 MES-SA and MCF-7 cells (IC50 3 nM for all) inhibits hypoxia-induced gene expression in an HRE reporter assay (IC50 8.7 nM) prevents lesion formation in TMV-infected tobacco plants at 500 Ug/ml inhibits protein synthesis by yeast and mammalian ribosomes
Meridian Life Science Liquid Stable Flex DNA qPCR, 800UL
Liquid Stable Flex DNA qPCR Mix is a combination of the latest advances in buffer chemistry and PCR enhancers and stabilizers, together with an antibody-mediated hot start polymerase and containing dUTP. Liquid Stable Flex DNA qPCR Mix has been designed to be stable for at least 12 months at ambient temperature. In addition, it has been optimized for highly reproducible and accurate assay, delivering exceptional performance in multiplex assays, even under fast thermal cycling conditions. Liquid Stable Flex DNA qPCR Mix formulation is compatible to applications where reduction of false positives from cross-over contamination is critical.
Biotium DNMT3A / DNA Methyltransferase 3 Alpha (PCRP-DNMT3A-1E2), CF740 conjugate, 0.1mg/mL
The specificity of this monoclonal antibody to its intended target was validated by HuProt™Array, containing more than 19,000, full-length human proteins. DNMT3A is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness
Biotium EZH2 / KMT6(EZH2/2536), CF740 conjugate, 0.1mg/mL
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Meridian Life Science Liquid Stable Flex DNA qPCR, 4ML
Liquid Stable Flex DNA qPCR Mix is a combination of the latest advances in buffer chemistry and PCR enhancers and stabilizers, together with an antibody-mediated hot start polymerase and containing dUTP. Liquid Stable Flex DNA qPCR Mix has been designed to be stable for at least 12 months at ambient temperature. In addition, it has been optimized for highly reproducible and accurate assay, delivering exceptional performance in multiplex assays, even under fast thermal cycling conditions. Liquid Stable Flex DNA qPCR Mix formulation is compatible to applications where reduction of false positives from cross-over contamination is critical.
Biotium CD43 (T-Cell Marker) (rSPN/1094), CF568 conjugate, 0.1mg/mL
This antibody recognizes a cell surface glycoprotein of 95/115/135 kDa (depending upon the extent of glycosylation), identified as CD43. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low ab
Medchemexpress LLC sEH inhibitor-7 | 340221-20-7 | 99.5% | 247.33 | 25 MG
sEH inhibitor-7 (compound c-2) is an inhibitor of soluble epoxide hydrolase (sEH) with IC50s of 0.15 μM (mouse sEH) and 6.2 μM (human sEH). Soluble epoxide hydrolase (sEH) plays an important role in the metabolism of endogenous chemical mediators involved in the regulation of blood pressure and inflammation.
- Inhibitor of soluble epoxide hydrolase (sEH)
- IC50s of 0.15 μM (mouse sEH) and 6.2 μM (human sEH)
- Plays an important role in the metabolism of endogenous chemical mediators
- Involved in the regulation of blood pressure and inflammation
- Purity: 99.5%
- Appearance: solid
- Color: off-white to light yellow
- Molecular weight: 247.33
- CAS No.: 340221-20-7
- Solubility: 100 mg/mL in DMSO
Enzo Life Sciences ODN 2006 (TLRGRADE™) (synthetic) (100µg)
CpG oligodeoxynucleotide (Type B) with phosphorothioate backbone. Specific ligand for human and mouse TLR9 (Toll-like receptor 9). Formulation: Lyophilized. Sterile. Long Term Storage: +4°C.
Biotium SOX9 / SRY-box 9 (PCRP-SOX9-1E5), CF488A conjugate, 0.1mg/mL
The specificity of this monoclonal antibody to its intended target was validated by HuProt™ Array, containing more than 19,000, full-length human proteins. Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. SOX9 plays an important role in the normal skeletal development. It may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are n
![Medchemexpress LLC 19,21-Dinorchol-4-en-20(22)-yn-3-one,17-hydroxy-23,23-dimethyl-11-[4-[methyl(1-methylethyl)amino]phe | 2222344-98-9 | 98.1% | 501.74 | 1 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000438547-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 19,21-Dinorchol-4-en-20(22)-yn-3-one,17-hydroxy-23,23-dimethyl-11-[4-[methyl(1-methylethyl)amino]phe | 2222344-98-9 | 98.1% | 501.74 | 1 MG
ORIC-101 is a highly potent and selective glucocorticoid receptor antagonist, with an EC50 of 5.6 nM. It has anti-cancer activity. Additionally, ORIC-101 is a click chemistry reagent, which means it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Highly potent and selective glucocorticoid receptor antagonist
- Anti-cancer activity
- Click chemistry reagent
- Contains an Alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups
Biotium CD43 (T-Cell Marker) (rSPN/1094), Biotin conjugate, 0.1mg/mL
This antibody recognizes a cell surface glycoprotein of 95/115/135 kDa (depending upon the extent of glycosylation), identified as CD43. 70-90% of T-cell lymphomas and from 22-37% of B-cell lymphomas express CD43. No reactivity has been observed with reactive B-cells. So a B-lineage population that co-expresses CD43 is highly likely to be a malignant lymphoma, especially a low-grade lymphoma, rather than a reactive B-cell population. When CD43 antibody is used in combination with anti-CD20, effective immunophenotyping of lymphomas in formalin-fixed tissues can be obtained. Co-staining of a lymphoid infiltrate with anti-CD20 and anti-CD43 argues against a reactive process and favors a diagnosis of lymphoma.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low ab
Biotium pS2 / pNR-2 / TFF1 (Estrogen-Regulated Protein)(rTFF1/1091), 0.2mg/mL
Recognizes a polypeptide of 6. 5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelih
Meso Scale Discovery U-PLEX Human vWF ASYQP
The Meso Scale Discovery U-PLEX Human VWF Assay is an electrochemiluminescent immunoassay for the quantitative measurement of von Willebrand Factor (VWF) in human serum plasma and cell culture supernatants This assay utilizes MSD s proprietary SULFO-TAG labels and multi-array technology to provide sensitive and reproducible quantitation of VWF with a wide dynamic range The assay requires a small sample volume and has a total assay time of approximately 3 5 hours The lower limit of detection is 1 3 ng/mL and the upper limit of quantitation is 10 000 ng/mL This assay provides a simple rapid high-throughput method for measuring VWF levels
