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Oligonucleotides with a wide variety of applications in microarrays, gel shift assays, artificial gene synthesis, PCR, DNA sequencing, molecular cloning, and other custom procedures. Available in multiple primer lengths; may be pre-designed or random.
MW 526.7 Da. Potent (IC₅₀ = nM; Ki = 3 nM) and specific EZH2 methyltransferase inhibitor. Selective against EZH1 (IC₅₀ = 633 nM). At least 4000-fold selective over a panel of 20 other human methyltransferases. Highly selective against a range of human histone deacetylases, GPCRs, kinases and ion channels. Reduces cellular H3K27me3 levels. Inhibits growth of diffuse large B-cell lymphoma cells. Inhinits melanoma growth and metastasis in mouse models.
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
5-FAM-Alkyne is a highly selective and sensitive fluorescent biosensor for alkaline phosphatase (ALP). It functions as a click chemistry reagent, featuring an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. The FAM fluorophore readily diffuses in solution, producing a strong fluorescence signal. This product is intended for research use only.
Highly selective and sensitive fluorescent biosensor for alkaline phosphatase (ALP)
Functions as a click chemistry reagent
Contains an alkyne group for click chemistry reactions
Small and Specialty Supplier Partner Small and/or specialty supplier based on Federal laws and SBA requirements. Learn More
The Meso Scale Discovery GAPDH Kit is a 96-well plate assay for the quantitative measurement of GAPDH in cell and tissue lysates It contains a 96-well plate coated with a GAPDH capture antibody a detection antibody conjugated to an electrochemiluminescent label and calibrator containing recombinant GAPDH The assay has a detection range of 1 56-200 ng/mL and takes 3 5 hours to complete It utilizes MSD s electrochemiluminescence technology for high sensitivity and wide dynamic range The kit includes all necessary reagents and can process up to 40 samples in duplicate It is designed for research use only
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
MW 390.5 Da. Potent (IC₅₀ = 15 nM for wild-type enzyme; 13 nM for Y641F mutant enzyme) EZH2 inhibitor. Selective versus EZH1 (142-fold). Highly selective (>10,000-fold) against a panel of 10 other human methyltransferases. Inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression in diffuse large B-cell lymphoma cells (DLBLC). Selectively inhibits growth and promotes cell cycle arrest and apoptosis of DLBLC cells with Y641 EZH2 mutations.