Oligonucleotides
New England Biolabs, Inc. LyoPrime Luna Probe One-Step RT-qPCR Mix with UDG - 96 rxns
The LyoPrime Luna Probe One-Step RT-qPCR Mix with UDG is offered in a lyophilized format, allowing for ambient/room temperature shipping and storage prior to use. The mix contains all necessary components for one-step RT-qPCR except primers, probe(s), and RNA sample. It can be reconstituted by simply adding water to a 2-4X concentration, allowing for increased sample input. Performance in multiplexing applications has been optimized, with sensitive, linear detection achieved for up to 5 targets across a range of inputs. It is available in 2 x 60 reaction glass vials or a 96-well plate (1 reaction per well).
New England Biolabs, Inc. EnGen SpRY Cas9 - 500 pmol
EnGen SpRY Cas9 from Streptococcus pyogenes is an engineered, RNA-guided, DNA endonuclease that catalyzes site-specific cleavage of double-stranded DNA (dsDNA).
New England Biolabs, Inc. LyoPrime WarmStart™ Fluorescent LAMP/RT-LAMP Mix (with UDG) - 100 rxns
The LyoPrime WarmStart Fluorescent LAMP/RT-LAMP Mix (with UDG) is offered in a lyophilized format, allowing for ambient/room temperature shipping and storage prior to use. It is a simple, one-step solution for real-time detection of LAMP/RT-LAMP reactions via fluorescence. LAMP and RT-LAMP are commonly used isothermal amplification techniques that provide rapid detection of a target nucleic acid using LAMP-specific primers and a strand-displacing DNA polymerase. Featuring a blend of Bst 2.0 WarmStart DNA Polymerase and WarmStart RTx Reverse Transcriptase in an optimized buffer solution, this mix offers improved performance. LAMP Fluorescent Dye at 0.5X concentration is included to enable detection of amplification via real time fluorescence. Antarctic Thermolabile UDG and dUTP reduce the risk of carryover contamination between reactions. It is available in 2 x 50 reaction glass vials or a 96-well plate (1 reaction per well).
New England Biolabs, Inc. Bst 2.0 WarmStart DNA Polymerase (Glycerol-free) - 8000 units
Bst 2.0 WarmStart DNA Polymerase (Glycerol-free) is formulated without glycerol to support lyophilization, incorporation into microfluidic devices, and enable quick adoption into automation workflows. Bst 2.0 WarmStart DNA Polymerase is an in silico designed homologue of Bacillus stearothermophilus DNA Polymerase I, Large Fragment (Bst DNA Polymerase, Large Fragment) with a reversibly-bound aptamer, which inhibits polymerase activity at temperatures below 45°C. At temperatures above 45°C, the aptamer rapidly releases from the enzyme with no special activation step needed to activate the polymerase. Bst 2.0 WarmStart DNA Polymerase contains 5' to 3' DNA polymerase activity and strong strand-displacement activity but lacks 5' to 3' exonuclease activity. Bst 2.0 WarmStart DNA Polymerase displays improved amplification speed, yield, salt tolerance, and thermostability compared to wild-type Bst DNA Polymerase, Large Fragment.
AdipoGen cGAMP 2Na STING Ligand
Chemical. CAS 849214-04-6 free acid. Formula C20H24N10O13P2 . 2Na. MW 674.4 . 46.0. Synthetic. Potent STING ligand. Second messenger in human and mouse cells that triggers interferon production in response to cytosolic DNA. Binding to STING leads to activation of IRF3 IFN regulatory factor 3 and the induction of interferon-beta. First cyclic nucleotide in metazoa. Plays a role in bacterial chemotaxis and colonization.
Abcam CPI-169, EZH2 inhibitor.
CPI-169, EZH2 inhibitor.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GSK503, EZH2 methyltransferase inhibitor, 5MG
MW 526.7 Da. Potent (IC₅₀ = nM; Ki = 3 nM) and specific EZH2 methyltransferase inhibitor. Selective against EZH1 (IC₅₀ = 633 nM). At least 4000-fold selective over a panel of 20 other human methyltransferases. Highly selective against a range of human histone deacetylases, GPCRs, kinases and ion channels. Reduces cellular H3K27me3 levels. Inhibits growth of diffuse large B-cell lymphoma cells. Inhinits melanoma growth and metastasis in mouse models.
The product is subject to the following: Abcam Restricted Use Statement
Abcam GSK503, EZH2 methyltransferase inhibitor, 50MG
MW 526.7 Da. Potent (IC₅₀ = nM; Ki = 3 nM) and specific EZH2 methyltransferase inhibitor. Selective against EZH1 (IC₅₀ = 633 nM). At least 4000-fold selective over a panel of 20 other human methyltransferases. Highly selective against a range of human histone deacetylases, GPCRs, kinases and ion channels. Reduces cellular H3K27me3 levels. Inhibits growth of diffuse large B-cell lymphoma cells. Inhinits melanoma growth and metastasis in mouse models.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SARS-CoV-2 Spike S1+S2 (mutated D80A + K417N + E484K + N501Y + D614G + A701V) protein (Active), 100UG
SARS-CoV-2 Spike S1+S2 (mutated D80A + K417N + E484K + N501Y + D614G + A701V) protein (Active) is a SARS-CoV-2 Fragment protein, in the 1 to 1213 aa range, expressed in Baculovirus infected insect, with =90% purity, < 1 EU/µg endotoxin level and suitable for SDS-PAGE, FuncS.
Protein/ Peptide/ Enzyme Synonyms: 2, S, Spike glycoprotein, S glycoprotein, E2, Peplomer protein
Conjugation: Unconjugated
The product is subject to the following: Abcam Restricted Use Statement
Abcam 1-Methylguanine, 250MG
MW 165.15 Da. Naturally occurring modified purine derived from tRNA, found in elevated levels in the serum and urine of cancer patients. (PMID: 2413515).
The product is subject to the following: Abcam Restricted Use Statement
Abcam EI1, EZH2 inhibitor, 50MG
MW 390.5 Da. Potent (IC₅₀ = 15 nM for wild-type enzyme; 13 nM for Y641F mutant enzyme) EZH2 inhibitor. Selective versus EZH1 (142-fold). Highly selective (>10,000-fold) against a panel of 10 other human methyltransferases. Inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression in diffuse large B-cell lymphoma cells (DLBLC). Selectively inhibits growth and promotes cell cycle arrest and apoptosis of DLBLC cells with Y641 EZH2 mutations.
The product is subject to the following: Abcam Restricted Use Statement
Abcam EI1, EZH2 inhibitor, 100MG
MW 390.5 Da. Potent (IC₅₀ = 15 nM for wild-type enzyme; 13 nM for Y641F mutant enzyme) EZH2 inhibitor. Selective versus EZH1 (142-fold). Highly selective (>10,000-fold) against a panel of 10 other human methyltransferases. Inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression in diffuse large B-cell lymphoma cells (DLBLC). Selectively inhibits growth and promotes cell cycle arrest and apoptosis of DLBLC cells with Y641 EZH2 mutations.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human GPC4 (Glypican 4) knockout HEK-293T cell line
Human GPC4 (Glypican 4) knockout HEK-293T cell line
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human POSTN (Periostin) knockout HeLa cell line
Human POSTN (Periostin) knockout HeLa cell line
The product is subject to the following: Abcam Restricted Use Statement