Oligonucleotides
![Apexbio Technology LLC tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus] 5mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000096613.png-250.jpg)
Apexbio Technology LLC tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus] 5mg
tumor protein p53 binding protein fragment is a protein fragment derived from Homo sapiens and Mus musculus that interacts with the central DNA-binding domain of tumor protein p53 It is designed to modulate p53-dependent transcriptional activation thereby influencing DNA damage response pathways tumor protein p53 binding protein fragment exerts its biological activity by participating in the cellular DNA damage response network particularly through ATM-dependent phosphorylation and localization to DNA damage foci following double-strand breaks Based on these properties tumor protein p53 binding protein fragment holds research potential in studying DNA damage signaling genomic stability and tumorigenesis mechanisms
BIOHIPPO AAV-NEFH-Cre-WPRE-hGH-polyA
Recombinant adeno associated virus expressing Cre under the NEFH promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
Abcam Spermine tetrahydrochloride, polyamine used for precipitation of DNA, 5G
MW 348.19 g/mol. Spermine is a biogenic polyamine formed from spermidine and occurs in almost all tissues. It is essential for both neoplastic and normal tissue growth. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. Spermine tetrahydrochloride is used for precipitation of DNA from low salt aqueous buffers.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC sEH inhibitor-1 (compound TCPU) | 1208549-68-1 | 99.6% | 10 MG
sEH inhibitor-1 (TCPU) is a potent, orally active inhibitor of soluble epoxide hydrolase (sEH) with low-nanomolar potency in human and murine assays. It is supplied as a high-purity research-grade compound for biochemical and pharmacological studies.
- Low-nanomolar potency (human IC50 0.4 nM; murine IC50 5.3 nM).
- Molecular formula C17H20F3N3O3 and molecular weight 371.35 g/mol.
- High purity suitable for research (99.62%).
- Available in small milligram pack sizes for in vitro and in vivo experiments.
- Targets soluble epoxide hydrolase for mechanistic and pharmacological studies.
ABclonal Technology Phospho-PTEN-S380 Rabbit pAb
This gene encodes a tumor suppressor protein that functions as a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin-like domain and a catalytic domain similar to dual specificity protein tyrosine phosphatases, but specifically dephosphorylates phosphoinositides. By regulating phosphatidylinositol-3,4,5-trisphosphate levels, it negatively controls the AKT/PKB signaling pathway. A non-canonical upstream initiation site produces a longer isoform associated with the mitochondrial inner membrane, potentially involved in energy metabolism regulation. A pseudogene of this gene is located on chromosome 9. Alternative splicing and multiple translation start sites result in various isoforms.
Medchemexpress LLC Tak1 protein, human (Sf9) | ≥98.0% | 20UG
Recombinant human TAK1 protein produced in Sf9 insect cells, supplied as a tag-free, highly purified preparation suitable for biochemical assays, kinase activity studies, and antibody validation. Provided in small-scale quantities; aliquot and store frozen to preserve activity.
- Tag-free recombinant human TAK1 protein.
- Expressed in Sf9 insect cells for eukaryotic post-translational modifications.
- High purity suitable for biochemical and cell-based assays.
- Low endotoxin level for sensitive applications.
- Supplied at a concentration that facilitates small-volume assays.
- Stable when stored at -80°C; avoid repeated freeze-thaw cycles.
Abcam GSK503, EZH2 methyltransferase inhibitor, 5MG
MW 526.7 Da. Potent (IC₅₀ = nM; Ki = 3 nM) and specific EZH2 methyltransferase inhibitor. Selective against EZH1 (IC₅₀ = 633 nM). At least 4000-fold selective over a panel of 20 other human methyltransferases. Highly selective against a range of human histone deacetylases, GPCRs, kinases and ion channels. Reduces cellular H3K27me3 levels. Inhibits growth of diffuse large B-cell lymphoma cells. Inhinits melanoma growth and metastasis in mouse models.
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology NCKAP1 Rabbit pAb
Contributes to small GTPase binding activity. Involved in Rac protein signal transduction, positive regulation of Arp2/3 complex-mediated actin nucleation, and positive regulation of lamellipodium assembly. Located in extracellular exosome and focal adhesion. Part of SCAR complex.
ABclonal Technology CXCR3 Rabbit pAb
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID12782716).
Cayman Chemical Precelys 2 mL Metal Tube 1ea
A stainless steel tube used in conjunction with the Precellys Evolution Touch (Item No. 38707)
ABclonal Technology GPC4 Rabbit pAb
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3 end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.
Ohiolumex Co Inc High-speed robust fiber-optic oxygen probe, REDFLASH technology, T90 < 0.5 s gas, T90 < 3 s water, 0-500 hPa oxygen, 1 bar max, 10 cm length, 3 mm diameter, 2 m cable, stainless steel, ST-connector
High-speed robust fiber-optic oxygen probe, REDFLASH technology, T90 < 0.5 s gas, T90 < 3 s water, 0-500 hPa oxygen, 1 bar max, 10 cm length, 3 mm diameter, 2 m cable, stainless steel, ST-connector
BIOHIPPO AAV-c-Fos-Cre-WPRE-hGH-polyA
Recombinant adeno associated virus expressing Cre under the c-Fos promoter with WPRE and hGH polyA elements. The Cre dependent configuration enables expression only after recombination, providing precise targeted control of targeted neurons. Offered under the Biohippo AAVX Series with multiple serotypes available including AAV2/1, AAV2/2, AAV2/5, AAV2/6, AAV2/6m, AAV2/6.2FF, AAV2/7m8, AAV2/8, AAV2/9, AAV2/DJ, AAV2/DJ8, AAV2/Retro, AAV2/PHP.eB, AAV2/PHP.B, AAV2/rh10, AAV2/PHP.S, AAV2/anc80, AAV2/B10, AAV2/olig001, AAV2/BI30, AAV2/BR1, AAV2/MG1.2, AAV1/2, AAV2/MaCPNS1, and AAV2/MaCPNS2. Regular titer is greater than or equal to 2.00E+12 vg per mL, with high titer greater than or equal to 1.00E+13 vg per mL available upon request at no additional cost. Customers may specify preferred serotype and titer when placing orders.
ABclonal Technology AVIL Rabbit pAb
The protein encoded by this gene is a member of the gelsolin/villin family of actin regulatory proteins. This protein has structural similarity to villin. It binds actin and may play a role in the development of neuronal cells that form ganglia.
Apexbio Technology LLC EZ Cap™ Cre mRNA (5-moUTP) 100ug (1mg/mL)
EZ Cap Cre mRNA 5-moUTP encodes Cre recombinase a tyrosine recombinase enzyme that facilitates homologous DNA recombination between two specific loxP recognition sites It is designed to promote precise DNA recombination thereby enabling conditional gene modification in mammalian systems EZ Cap Cre mRNA 5-moUTP exerts its biological activity primarily through expression of Cre recombinase which catalyzes site-specific recombination at loxP sites This mRNA incorporates a Cap 1 structure and 5-methoxyuridine triphosphate (5-moUTP) modification to reduce innate immune responses and improve translational stability Based on these properties EZ Cap Cre mRNA 5-moUTP holds research potential in genome editing experiments conditional gene knockout studies and reporter gene activation in mammalian research models