Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter U2OS ErbB1 Functional Assay, 2 vials. (93-0863C3)
The PathHunter U2OS ErbB1 Functional Assay provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting RTKs. This kit assesses RTK activation via detection of activated ErbB1 dimerization-induced SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses ProLink-tagged ErbB1 and an EA-tagged SH2 domain protein. Upon ligand-induced receptor activation, SH2-EA recruitment leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx PathHunter U2OS FOXO3 Nuclear Translocation Cell Line, 2 vials. (93-0876C3)
The PathHunter U2OS FOXO3 Nuclear Translocation Cell Line is a stable, engineered cell line for use in studying drug candidates affecting the PI3 pathway. This cell line enables assessment of ligand (e.g. wortmannin) based pathway activation via detection of resulting FOXO3 nuclear translocation. This product uses EFC technology. The included cell line overexpresses ProLabel-tagged FOXO3 and nuclear localized EA. Upon pathway activation, induced nuclear translocation of FOXO3 leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/pathways.
Genscript Corporation CHO-K1/ADRA2B/Gqi5 Stable Cell
Adrenoceptors are 7-transmembrane receptors which mediate the central and peripheral actions of the neurotransmitter noradrenaline (norepinephrine) and the hormone and neurotransmitter adrenaline (epinephrine) Based on both pharmacological and molecular evidence they are divided into three major types - 1 2 and The 2 adrenoceptors include 3 subtypes - 2A 2B and 2C - each of which couples to G sub i/o /sub protein primarily br The 2B adrenoceptors (ADRA2B) is expressed in the kidney liver brain lung heart and skeletal muscle The development of 2B and 2C knock-out mice has shown that these two subtypes are not involved in the central hypotensive response to 2 agonists
iQ Biosciences C57BL/6 Mouse Irradiated Splenocytes, 25M cells/vial
High-quality, high-viability (typically > 70%) irradiated splenocytes from the C57BL/6 mouse, the most commonly-used inbred mouse strain. Used for a wide variety of immunology-based applications, including proliferation and cytotoxicity studies. All orders come with an iQ Certificate of Analysis.
Genscript Corporation HEK293/AT1 Stable Cell Line
Recombinant HEK293 cells stably overexpress human angiotensin II receptor type 1 (AT1) on the surface and contain high levels of G protein G q to couple with the receptor in downstream signaling pathways
Eurofins Discoverx PathHunter U2OS NIK Signaling Assay, 2 vials. (93-1059C3)
The PathHunter NIK Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of ligand (e.g. CD40, TWEAK) induced non-canonical NF-κB signaling via detection of NIK stabilization. This product uses EFC technology. The included cell line overexpresses ED-tagged NIK (NF-kappa-B Inducing Kinase) protein. Upon activation of NFκB signaling by a ligand or an antibody, NIK is stabilized, allowing detection of EFC signal when treated with exogenous EA. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/checkpoint.
BPS Bioscience Inc BCMA / NF- KBREPORTER HEK293
BCMA / NF - kB Reporter HEK293 Recombinant Cell Line | Size: Two vials containing approx 2 x 106 cells in 1 ml of 10% DMSO in FBS
Lonza Walkersville Mouse C57BL/6 Hepatocytes, Cryopreserved, Plateable
Cryopreserved C57BL/6 Mouse Hepatocytes, Plateable are specifically pre tested for metabolic activity of general Phase I and Phase II metabolism in suspension.They are tested for healthy morphology lasting 72 hours in monlayer sandwich culture.Applications:Drug metabolism in plated monolayer formatSpecies-species comparisonsGenomicsContent:1 x Cryopreserved ampule of C57BL/6 Mouse Hepatocytes (plateable format) containing > 5 million viable cells
Genscript Corporation CHO-K1/CASR Stable Cell Line
CASR is a calcium-sensing receptor and plays an important role in regulating PTH secretion It is expressed in many different tissues such as parathyroid pancreatic islet and insulinoma cells breast gastrinoma cells pituitary keratinocytes and human colon epithelial cells CASR Inhibits PTH secretion and parathyroid cellular proliferation in parathyroid glands or cells and also inhibits proliferation of colonic crypt cells Besides it can stimulate PTHrP secretion in prostate cell line and stimulate calcitonin secretion from thyroidal C-cells
Genscript Corporation CHO-K1/D2s/G15 Stable Cell Li
The short form of D2 (D2S) and the long form (D2L) are two isoforms that contribute differentially to dopamine signaling in both prefrontal cortex and striatum The D2 dopamine receptor short form (D2s) has been shown to stimulate phospholipase D (PLD) activity independent of the activation of phospholipase C (PLC) activity in GH4 derived cells stably transfected with the D2s receptor Agonist activation of D2s has been shown to mediate the inhibition of growth in the same cell line
Sigma Aldrich Fine Chemicals Biosciences Mesenchymal Stem Cell Chon
Mesenchymal Stem Cell Chondrogenic Differentiation Medium (Ready-to-use)
Amsbio LLC Lyophilized exosomes from NCI-H1975 cell line
Lyophilized exosomes from NCI-H1975 cell line