General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter CHO-K1 NPY1R β-Arrestin Cell Line, 2 vials. (93-0397C2)
The PathHunter NPY1R cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. peptide YY) based activation of NPY1R GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged NPY1R and EA-tagged β-Arrestin-2. Activation of NPY1R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 PROKR2 β-Arrestin Cell Line, 2 vials. (93-0282C2)
The PathHunter PROKR2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prokinectin, EG-VEGF) based activation of PROKR2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged PROKR2 and EA-tagged β-Arrestin-2. Activation of PROKR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Sigma Aldrich Fine Chemicals Biosciences Human Dermal fibroblasts
Dermal fibroblasts are responsible for producing the extracellular matrix forming the connective tissue of the skin and play a crucial role during wound healing. HDf provide an excellent model system to study many aspects of cell physiology and have been utilized in dozens of research publications particularly those related to skin biology and reprogramming/induced pluripotency studies. HDf were used to create along with human synovyocytes induced pluripotent stem cells (iPSC) by using the now classic Yamanaka cocktail of Oct3/4 Sox2 Klf4 and c-Myc the discovery for which Dr. Shinya Yamanaka was awarded the Nobel Prize in 2012 (Takanashi 2007 2009) and to characterize iPSC general properties miRNA expression profiles and differentiation potential (Hayashi 2010 Ohta 2011 Koyanagi-Aoi 2013 Noguchi 20130 Razak 2013 Sakurai 2013 Tanaka 2013 Yanagida 2013)
ATCC Talaromyces varians
An ampoule containing viable cells (may include spores and mycelia) suspended in cryoprotectant.
Eurofins Discoverx PathHunter U2OS P2RY2 β-Arrestin Cell Line, 2 vials. (93-0628C3)
The PathHunter P2RY2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. UTP) based activation of P2RY2 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged P2RY2 and EA-tagged β-Arrestin-2. Activation of P2RY2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx ChemiScreen CRTH2/DP2 Prostanoid Receptor Membrane Preparation, 1 vial. (HTS031M)
The ChemiScreen CRTH2/DP2 Prostanoid Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of PTGDR2 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach or to screen for GPCR activity using GTPγS assays. Increased binding affinities or GPCR activation levels will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Medchemexpress LLC GIP Human HEK293 50ug
The GIP protein is a member of the glucagon superfamily an important incretin hormone that stimulates pancreatic beta cells to secrete insulin in response to food intake Through its G protein-coupled receptor it activates adenylyl cyclase and other signal transduction pathways GIP Protein Human (HEK293 hFc) is the recombinant human-derived GIP protein expressed by HEK293 with C-hFc labeled tag
ATCC Chlamydophila pneumoniae; Strain: 2023
Chlamydophila pneumoniae TWAR strain 2023 is propagated in HEp-2 cells (ATCC CCL-23). This bacterial strain was isolated from the nasopharynx of a human patient with pneumonia and can be used in infectious disease and respiratory disease research.
Biochain Institute Inc Matched Pair - DNA - Human Primary Tumor and Normal Tissue: Lung, 2x10 ug/PK
BioChain's human DNA matched pair products include: Primary Pair (PP), Primary and Metastasis Pair (PM). PP consists of DNA prepared from primary tumor and its adjacent normal tissue; PM consists of DNA prepared from primary tumor and corresponding ponding metastatic tumor. Genomic DNA in each pair is prepared from the same donor. This product line is designed foridentifying tumor-specific genes and tumor metastatic genes.
Eurofins Discoverx PrecisION hCav3.2 Recombinant Stable Cell Line, 2 vials. (CYL3075)
The PrecisION hCav3.2 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying Cav3.2 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses Cav3.2 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
ATCC Salmonella enterica; subsp. enterica; serovar Bispebjerg
Bacteriophage host. Used as a control strain for the detection of Salmonella and in the examination of dairy products.
ATCC Pfizer Pneumococcal polysaccharide powder Type 5 (d5) 200mg
Purified pneumococcal polysaccharide type 5 is manufactured by Pfizer, Inc., for small-quantity distribution by ATCC. The pneumococcal powder type 5 (200 mg) is a component of the current 13-valent vaccine against Streptococcus pneumoniae. The pneumococcal polysaccharide type 5 can be used to assay for type-specific antibodies, research immune responses, and study immunodeficiencies.
ATCC Rhizobium rhizogenes
Rhizobium rhizogenes strain [CIP 104786] is a whole-genome sequenced strain that produces isoprene. This bacterium has applications in agricultural research.