General Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/MCH2 Stable Cell Line
Coupled exclusively Gq MCH2 is a receptor for melanin-concentrating hormone Other than regulating skin color two subtypes (MCHR1 and MCHR2) are involved in energy homeostasis and social behaviors In contrast to MCHR1 that is conserved among all mammals functional MCHR2 is only expressed in carnivores and primates but not in rodents
ATCC NCI-H2106; Non-Small Cell Lung Cancer; Human (Homo sapiens)
NCI-H2106 [H2106] is a cell line exhibiting floating clusters morphology that was isolated from the lungs of a 58-year-old, White male patient with stage 4 non-small cell lung cancer. This product has applications in cancer research.
ATCC Influenza A virus (H3N2); A/Aichi/2/68
Influenza A virus (H3N2) strain A/Aichi/2/68 is propagated in SPF embryonated chicken eggs. This strain was isolated in 1968 from a sailor on an Israeli ship docking at Aichi, Japan. This product has applications in influenza research and respiratory disease research.
Eurofins Discoverx PathHunter CHO-K1 GPR18 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0560C2A)
The PathHunter GPR18 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand based activation of GPR18 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR18 and EA-tagged β-Arrestin-2. Activation of GPR18 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. This is an orphan receptor without a known ligand. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 rDRD2L (Long Isoform) β-Arrestin Cell Line, 2 vials. (93-0785C2)
The PathHunter rDRD2L cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. dopamine) based activation of rDRD2L GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged rDRD2L and EA-tagged β-Arrestin-2. Activation of rDRD2L stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Rat version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Frozen Tissue Array - Rabbit Female Adult Normal Tissue, Multi-tissue I, 1 slide/PK
BioChain's rabbit normal multiple frozen tissue arrays are designed for studying tissue specific cellular localization of genes or proteins of interest in different rabbit tissues. Up to 30 different frozen tissues from the same male or female rabbit are mounted on positively charged glass slides. Total RNA and cDNA from those tissues may also be available upon request.
Eurofins Discoverx cAMP Hunter CHO-K1 PTHR2 Gs Cell Line, 2 vials. (95-0057C2)
The cAMP Hunter PTHR2 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. parathyroid hormone, TIP 39) based activation of PTHR2 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type PTHR2, a naturally Gs coupled GPCR. Upon activation of PTHR2, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter CHO-K1 GPR55 β-Arrestin Cell Line, 2 vials. (93-0245C2)
The PathHunter GPR55 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. lysophosphatidylinositol) based activation of GPR55 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR55 and EA-tagged β-Arrestin-2. Activation of GPR55 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Frozen Tissue Section - Multiple Sclerosis Disease: Brain: Hippocampus, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx InCELL Hunter U2OS MCL1-BIM Protein Binding Cell Line, 2 vials. (96-0075C3)
The InCELL Hunter U2OS MCL1-BIM Protein Binding Cell Line provides an easy-to-use cell based assay to study small molecule drug candidates that disrupt protein binding. This kit assesses compound-based disruption of MCL1-BIM binding via detection of BIM levels. This product uses EFC technology. The cell line included overexpresses MCL1 target in an untagged form and BIM binding partner fused to ProLabel. When a compound engages the MCL1 target protein, partner binding is disrupted and the destabilized BIM is degraded, leading to a loss of EFC signal upon addition of EA containing detection reagent. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Biochain Institute Inc Frozen Tissue Section Panel - Monkey (Rhesus) Normal Tissue, Multi-tissue I, 5 slides/PK
BioChain's Rhesus monkey normal multiple frozen tissue panels are designed for studying tissue specific cellular localization of genes or proteins of interest in different monkey tissues. 8 different frozen tissues are mounted on positively charged glass slides. Total RNA Northern Blots are available in the identical format, and cDNA from those tissues may also be available for PCR detection.
Eurofins Discoverx PathHunter CHO-K1 mAVPR2 β-Arrestin Cell Pool, 2 vials. (93-0596P2)
The PathHunter mAVPR2 cell pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. vasopressin) based activation of mAVPR2 GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mAVPR2 and EA-tagged β-Arrestin-2. Activation of mAVPR2 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.