General Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/EDNRB Stable Cell Line
In mammals the endothelin (ET) family comprises three endogenous isoforms ET-1 ET-2 and ET-3 These endothelium-derived peptides perform their functions via two endothelin receptors classified as EDNRA and EDNRB EDNRB receptors present on the endothelial cells lining the vessel wall and play a role in the release of endothelium-derived relaxing factors such as nitric oxide (NO) and prostanoids and in removing ET from the circulation
Genscript Corporation CHO-K1/ADORA2A/G15 Stable Cel
Recombinant CHO-K1 cells stably overexpress human adenosine A2A receptor (ADORA2A) on the surface and contain high levels of G protein G s to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/G15/CXCR1
Chemokine (C-X-C motif) receptor 1 (CXCR1) is a rhodopsin-like G protein-coupled receptor It is one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL-8) a major mediator of immune and inflammatory responses The structure of human CXCR1 in a lipid bilayer should help to facilitate the discovery of new compounds that interact with GPCRs GenScript s human CXCR1-expressing stable subline is guaranteed to function properly in the calcium flux assay
Genscript Corporation CHO-K1/CysLT1/G15 Stable Cell
CysLT1 (Cysteinyl leukotriene receptor 1) is previous named as LTD4 receptor (leukotriene D4 receptor) It is a receptor for cysteinyl leukotrienes and has highest affinity to leukotriene D4 (LTD4) The receptor mediates contraction and proliferation of smooth muscle edema eosinophil migration and damage to the mucus layer in the lung caused by LTD4 A CysLT1 selective antagonist montelukast is used clinically in the treatment of asthma This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system The rank order of affinities for the leukotrienes is LTD4 LTE4 LTC4 LTB4
Genscript Corporation CHO-K1/mouse PD-L1 Stable Cell
Recombinant CHO-K1 cells stably overexpress mouse programmed cell death 1 ligand 1 (PD-L1) on the surface The surface expression of PD-L1 is validated by FACS analysis
Genscript Corporation CHO-K1/Cyno CD47 Stable Cell L
This gene encodes a membrane protein which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin and it may play a role in membrane transport and signal transduction This gene has broad tissue distribution and is reduced in expression on Rh erythrocytes Alternatively spliced transcript variants have been found for this gene
Genscript Corporation CHO-K1/ADRA2C/G15 Stable Cell
The adrenoceptors ADRA2C is expressed in the brain kidney aorta lung skeletal muscle heart and spleen ADRA2C knockout mice exhibited disrupts presynaptic inhibition of noradrenaline release at low stimulation frequencies
Genscript Corporation CHO-K1/Mouse VISTA Stable Cell
V-domain Ig suppressor of T cell activation (VISTA) is a potent negative regulator of T-cell function that is expressed on hematopoietic cells VISTA levels are heightened within the tumor microenvironment in which its blockade can enhance antitumor immune responses in mice In humans blockade of the related programmed cell death 1 (PD-1) pathway has shown great potential in clinical immunotherapy trials
Genscript Corporation CHO-K1/mouse CD155 Stable Cell
CD155 commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5) is a type I transmembrane single-span glycoprotein and belongs to the nectins and nectin-like (Necl) subfamily CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV) an etiologic agent of the central nervous system disease poliomyelitis The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells CD155 may assist in an efficient humoral immune response generated within the intestinal immune system It s been shown that CD155 can be recognized and bind by DNAM-1 and CD96 which promotes the adhension migration and NK-cell killing Thus inducing cell-mediated tumor-specific immunity
Abcam Tandospirone hydrochloride (Metanopirone), 5-HT1A partial agonist, 50MG
MW 419.9 Da, Purity >99%. Potent, selective 5-HT1A partial agonist (Ki = 27 nM). Decreases the firing rate of 5-HT neurons of the dorsal raphe. Shows anxiolytic and antidepressant effects *in vivo.* Orally active.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Taurine, Partial glycine receptor agonist, 1G
MW 125.15 Da, Purity >98%. Partial glycine receptor agonist. Abundant free amino acid in the retina and central brain and elicits a variety of biological effects. Able to cross the blood-brain barrier.
The product is subject to the following: Abcam Restricted Use Statement
Abcam TCS O x 2 29, Ore x in-2 receptor antagonist, 10MG
MW 434 Da, Purity >98%. Potent, selective orexin-2 receptor antagonist (IC₅₀ = 40 nM). Neurological and insomnia agent. Active in vitro and in vivo.
The product is subject to the following: Abcam Restricted Use Statement
Electron Microscopy Sciences Style 709, Material: Delrin., 1/EA
Full plastic tweezers. Material: Delrin. OAL: 115 mm .
Eurofins Discoverx Ready-to-Assay µ Opioid Receptor Frozen Cells, 2 Vials of Cells. (HTS101RTA)
The Ready-to-Assay µ Opioid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. opioids) based activation of OPRM1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses OPRM1 alongside exogenous levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of OPRM1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.