General Cell Lines and Cell Cultures
Lifeline Cell Technology M KERATOCYT LIFELINE KT
Includes DermaLife Serum-Free Basal Medium 485 mL, DermaLife K LifeFactors Kit. Optimized for the culture of human keratinocytes over a period of at least 15 population doublings. Contains no antimicrobials and no phenol red.
Lifeline Cell Technology CELLS PUL ART END HU LIFELN VL
Normal Human Pulmonary Artery Endothelial Cells (HPAEC), when grown in Lifeline's VascuLife Medium, provide an ideal low-serum culture model, with or without human VEGF, for the study of angiogenesis, atherosclerosis or vascular biology.
Electron Microscopy Sciences Style 709, Material: Delrin., 1/EA
Full plastic tweezers. Material: Delrin. OAL: 115 mm .
Abcam BD 1047 dihydrobromide, sigma1 receptor antagonist, 10MG
MW 437 Da, Purity >99%. Selective σ1 receptor antagonist. Shows centrally-mediated antianalgesic, antiaddictive and antidystonic effects in vivo. Blood-brain barrier permeable.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SKF 97541, Highly GABAB agonist, 10MG
MW 137.12 Da, Purity >98%. Highly potent GABAB agonist, 10-fold more potent than Baclofen (ab120149). (EC50 values for depression of striatal synaptic potentials are 920 nM and 1.25 μM for SKF97541 and baclofen, respectively). Also available in simple stock solutions (ab146688) - add 1 ml of water to get an exact, ready-to-use concentration.
The product is subject to the following: Abcam Restricted Use Statement
Abcam SNC80, delta opioid receptor agonist, 50MG
MW 449.64 g/mol, Purity >99%. Highly potent and selective δ opioid receptor agonist (Ki = 9.4 nM). Centrally active following systemic administration. Displays antidepressant activity.
The product is subject to the following: Abcam Restricted Use Statement
Abcam AH-7614, FFA4/GPR120 antagonist, 25MG
MW 351.4 Da. Selective FFA4/GPR120 antagonist. Inhibits linoleic acid (ab141144)-induced intracellular calcium accumulation.
The product is subject to the following: Abcam Restricted Use Statement
Invivogen A549 LUNG CARCINOMA CELLS EXPR
A549 lung carcinoma cells expressing human ACE2 and human TMPRSS2
Eurofins Discoverx PathHunter C2C12 CXCR4 β-Arrestin Cell Line, 2 vials. (93-0203C7)
The PathHunter CXCR4 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. [ligand]) based activation of CXCR4 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CXCR4 and EA-tagged β-Arrestin-2. Activation of CXCR4 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PrecisION hnAChR α7/ric3 Recombinant Stable Cell Line, 2 vials. (CYL3097)
The PrecisION hnAChR α7/ric3 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying nAChR α7/ric3 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses nAChR α7/ric3 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
Eurofins Discoverx PathHunter U2OS CXCR3 β-Arrestin Cell Line, 2 vials. (93-0271C3)
The PathHunter CXCR3 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CXCL11/I-TAC) based activation of CXCR3 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CXCR3 and EA-tagged β-Arrestin-2. Activation of CXCR3 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx ChemiBrite EP1 Prostanoid Receptor Stable Cell Line, 2 vials. (HTS099L)
The ChemiBrite EP1 Prostanoid Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin E2) based activation of PTGER1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTGER1, a naturally Gq coupled GPCR. ChemiBrite cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of PTGER1, the resulting calcium activity can be assayed in either detection mode. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay PK2 Prokinecticin Receptor Frozen Cells, 2 Vials of Cells. (HTS182RTA)
The Ready-to-Assay PK2 Prokinecticin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. prokinectin, EG-VEGF) based activation of PROKR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PROKR2 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of PROKR2, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.