General Cell Lines and Cell Cultures
Eurofins Discoverx InCELL Hunter HEK 293 BLK Kinase Binding Cell Line, 2 vials. (96-0044C1)
The InCELL Hunter HEK 293 BLK Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of BLK via detection of BLK levels. This product uses EFC technology. The cell line included overexpresses BLK target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Eurofins Discoverx InCELL Hunter A549 PIM1 Kinase Binding Cell Line, 2 vials. (96-0052C15)
The InCELL Hunter A549 PIM1 Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of PIM1 via detection of PIM1 levels. This product uses EFC technology. The cell line included overexpresses PIM1 target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/kinases.
Miltenyi Biotec, Inc. CD278 (ICOS)-FITC, h, m, r, REA192, 30 t
Identification and enumeration of CD278 (ICOS)+ cells by flow cytometry.
This product is subject to the following: Miltenyi Biotec, Inc. Terms and Conditions of Sale For Products and Services
Lonza Walkersville D-HCAEC - Diabetes Type II
Diseased human coronary artery endothelial cells are isolated from human donors that have been diagnosed with diabetes type I or type II disease Diseased cells are grown in the same optimized media system as Normal Human Endothelial Cells Diabetic cultures can be used for experimental applications in diabetic-related cardiovascular pharmaceutical development vascular pathology including atherosclerosis Cryopreserved Clonetics Diabetic Human Coronary Artery Endothelial Cells are shipped in third passage Proliferating Clonetics cells are shipped in fourth passage All cells test negative for mycoplasma bacteria yeast and fungi HIV-1 hepatitis B and hepatitis C are not detected for all donors and/or cell lots A Certificate of Analysis is provided for each cell lot purchased
Lonza Walkersville D-SAEC-COPD - COPD
Chronic bronchitis is marked by long-term cough and excess mucous Emphysema leads to the destruction of the lungs over time Most people with COPD have a combination of both conditions Usually COPD is associated with bronchial epithelium changes Lonza s Human Small Airway Epithelial Cells (SAEC) with COPD are isolated from diseased human lung tissue from COPD donors Cells are isolated from the distal portion of the lung in the 1mm bronchiole area All cells test negative for mycoplasma bacteria yeast and fungi HIV-1 hepatitis B andhepatitis C are not detected for all donors and/or cell lots A Certificate of Analysis is provided for each cell lot purchased
Eurofins Discoverx cAMP Hunter CHO-K1 rDRD1 Gs Cell Line, 2 vials. (95-0128C2)
The cAMP Hunter rDRD1 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. dopamine, A68930) based activation of rDRD1 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type rDRD1, a naturally Gs coupled GPCR. Upon activation of rDRD1, the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Rat version of this protein. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Biochain Institute Inc Paraffin Tissue Section Panel - Human Tumor, Same Tumor Type, Different Donors (5 tissues), 5 slides/PK
BioChain's FFPE multiple tissue panels from the same type of tumors are designed for rapidly screening expression of tumor specific genes or proteins. Tumor tissue sections with the same tissue type collected from three different donors are arrayed along with a corresponding normal control tissue section on positively charged glass slides. Documentation of tissues' clinical histories may be available upon request. Human placenta tissue section is included in each panel as an interpanel control for comparison between different tissue panels.
Eurofins Discoverx ChemiScreen PAF Platelet Activating Factor Receptor Stable Cell Line, 2 vials. (HTS076C)
The ChemiScreen PAF Platelet Activating Factor Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. PAF) based activation of PTAFR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses PTAFR alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of PTAFR, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.