General Cell Lines and Cell Cultures
ATCC LLC-PK1, Kidney; Pig (Sus scrofa)
LLC-PK1 is a cell exhibiting epithelial morphology that was isolated from the kidney of a male 3-4 weeks pig. This cell line was deposited by Eli Lilly & Co.
ATCC NCI-H1882; Lung Carcinoma; Human (Homo sapiens)
NCI-H1882 [H1882] is a cell line exhibiting epithelial morphology that was isolated from the lungs of a patient with stage E small cell lung cancer: carcinoma. This product has applications in cancer research and immunology.
ATCC Acinetobacter baumannii; Strain 2208; genomic DNA
Genomic DNA isolated from Acinetobacter baumannii strain 2208 (ATCC 19606). This whole-genome sequenced product can be used in PCR and other molecular biology applications.
ATCC Escherichia coli
Escherichia coli strain J53 pMG224 is a multidrug-resistant bacterium that produces extended spectrum beta-lactamase (ESBL) TEM-12. This strain is whole-genome sequenced and has applications in antimicrobial resistance research.
ATCC Akkermansia muciniphila; Strain: m1-15
Akkermansia muciniphila strain m1-15 is a bacterial strain that was isolated from the cecal contents of a thirteen-lined ground squirrel (Ictidomys tridecemlineatus). This strain has mucin-dependent growth.
ATCC Rhodotorula mucilaginosa
An ampoule containing viable cells (may include spores and mycelia) suspended in cryoprotectant.
Eurofins Discoverx ChemiScreen SUCNR1/GPR91 Succinate Receptor Stable Cell Line, 2 vials. (HTS241C)
The ChemiScreen SUCNR1/GPR91 Succinate Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. succinate) based activation of SUCNR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses SUCNR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of SUCNR1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Genscript Corporation CHO-K1/B7-H2 Stable Cell Line
Ligand for the T-cell-specific cell surface receptor ICOS acts as a costimulatory signal for T-cell proliferation and cytokine secretion It also induces B-cell proliferation and differentiation into plasma cells It could also play an important role in mediating local tissue responses to inflammatory conditions as well as modulating the secondary immune response by co-stimulating memory T-cell function
Eurofins Discoverx Ready-to-Assay M5 Acetylcholine (Muscarinic) Receptor Frozen Cells, 2 Vials of Cells. (HTS075RTA)
The Ready-to-Assay M5 Acetylcholine (Muscarinic) Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. acetylcholine) based activation of CHRM5 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CHRM5 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of CHRM5, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
ATCC Human Coxsackievirus A21; Strain: Kuykendall
Human Coxsackievirus A 21 strain Kuykendall [V-024-001-012] is propagated in WISH cells (ATCC CCL-25). This strain was isolated in 1952 from the stool of a 17-year-old human male with paralytic illness and was deposited by NIH/NIAID. This product has applications in respiratory disease research.
Genscript Corporation CHO-K1/LTB4/G15 Stable Cell L
The dihydroxy-leukotriene leukotriene B4 (LTB4) is a member of the G protein-coupled receptor (GPCR) family in a subfamily of GPCRs that includes receptors for chemokines and other chemotactic factors Recently a second lower affinity receptor for LTB4 (BLT2) has also been cloned with broader ligand specificity for various eicosanoids LTB4 stimulates neutrophil chemotaxis and secretion but may also affect immunomodulation contraction of certain smooth muscles via an indirect mechanism and activation of the nuclear transcription factor PPAR (peroxisome proliferation activated receptor alpha) Chemotaxis the principal effects of LTB4 and related dihydroxy-acids on leukocytes occurs via activation of BLT1 receptors
ATCC Mycobacterium peregrinum
Mycobacterium peregrinum strain MF1353 [CDC 97-1188] was isolated in Greenville, North Carolina, from the sputum of an immunocompromised patient. This whole-genome sequenced bacterial strain has applications in susceptibility disc testing.
ATCC 209/MDCT; Distal Convoluted Tubule; Mouse (Mus musculus)
209/MDCT is a distal convoluted tubule cell line that was isolated in 1998 from the kidney of a 44-to-55-day-old, male mouse. This continous line of distal convoluted tubule (DCT) cells were immortalized with Adenovirus 12 - SV40 virus hybrid (Ad12-SV40). They express a phenotype including NaCl cotransporter (Slc12a3) and PTH receptors. The DCT is a primary site for regulation of blood pressure by controlling NaCl absorption and for calcium homeostasis by parathyroid hormone. This cell line is of considerable use for studies of hormonal and pharmacological regulation of fundamental ion transport processes and their underlying mechanisms. This cell line was deposited by Friedman, PA.
ATCC PHM1-41; Myometrium; Human (Homo sapiens)
PHM1-41 is a fibroblast cell line isolated in 1992 from the uterus of a pregnant female obtained at the time of elective cesarean section at 39 weeks gtestation. The myometrial cells were isolated by enzymatic digestion and retain many morphological and phenotypic responses in common with cultured primary myometrial cells. They are useful for long-term or coordinated studies, as their behavior is quite reproducible and the alternative to obtain material from patients is labor intensive and variable.
Eurofins Discoverx Ready-to-Assay MCH1 Melanin-Concentrating Hormone Receptor Frozen Cells, 2 Vials of Cells. (HTS025RTA)
The Ready-to-Assay MCH1 Melanin-concentrating Hormone Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. MCH) based activation of MCHR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses MCHR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of MCHR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.