General Cell Lines and Cell Cultures
Eurofins Discoverx PathHunter CHO-K1 GPR23 β-Arrestin Orphan GPCR Cell Line, 2 vials. (93-0336C2A)
The PathHunter GPR23 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. LPAs) based activation of GPR23 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged GPR23 and EA-tagged β-Arrestin-2. Activation of GPR23 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx cAMP Hunter CHO-K1 PPYR1 (NPY4R) Gi Cell Line, 2 vials. (95-0087C2)
The cAMP Hunter PPYR1 (NPY4R) Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. pancreatic polypeptide, peptide YY) based activation of PPYR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type PPYR1, a naturally Gi/Go coupled GPCR. Upon activation of PPYR1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Cayman Chemical ApelIn-12humnmouserat1mg
An endogenous agonist of the APJ receptor; induces calcium mobilization in APJ-Gαq16 cells expressing human APJ (EC50 = 0.18 nM); inhibits HIV-1 and HIV-2 infection in NP-2/CD4/APJ cells (mean IC50 = 63 UG/ml); inhibits or stimulates the expression of genes associated with apoptosis, mitosis, and DNA repair in IEC-6 and Caco-2 cells, respectively, at 0.01 µM; induces the production of NO in HUVECs from 100-1,000 nM; increases gastric acid secretion, as well as stomach histamine synthesis and secretion in rats from 20-100 UG/kg; reduces MAP in rats at 15 UG/kg
Eurofins Discoverx cAMP Hunter CHO-K1 ADORA1 Gi Cell Line, 2 vials. (95-0061C2)
The cAMP Hunter ADORA1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. adenosine, NECA) based activation of ADORA1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type ADORA1, a naturally Gi/Go coupled GPCR. Upon activation of ADORA1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
Eurofins Discoverx PathHunter U2OS SSTR1 β-Arrestin Cell Line, 2 vials. (93-0307C3)
The PathHunter SSTR1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin) based activation of SSTR1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged SSTR1 and EA-tagged β-Arrestin-2. Activation of SSTR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/gpcr.
iQ Biosciences Purified Rhesus Monkey CD14+ Cells, 2M cells/vial
High-quality, high-viability (> 90%) CD14+ cells purified from rhesus macaque peripheral blood mononuclear cells (PBMC) by magnetic isolation. Highly enriched (typically > 90%) post-selection purity achieved via magnetic isolation. Ideal source for rhesus monocytes and neutrophils. Used for a wide variety of safety assessment and functional assays. All orders come with an iQ Certificate of Analysis.The following donor requests can be accommodated if inventory is available:- Single or multiple donors for a particular product (SKU). Indicate number of vials from each individual donor- Donor-matched PBMCs
Eurofins Discoverx PrecisION hKv1.4 Recombinant Stable Cell Line, 2 vials. (CYL3017)
The PrecisION hKv1.4 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying Kv1.4 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses Kv1.4 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/ion-channels.
Cayman Chemical 9-cIs RetInal 1mg
A natural retinoid that is produced by oxidation of 9-cis retinol by cRDH; binds to CRBP-I, CRBP-II, and CRALBP (Kds = 8, 5, and 53.3 nM, respectively); inhibits differentiation of RCJ C5.18 chondrogenic cells into cartilage in vitro (IC50 = 8 nM); it rescues cone ERG responses in Irbp-/- mice (0.375 mg)
Med Vet International Vienna Nasal Speculum, 5.25in, Size 2, German Grade, Von Klaus
Vienna Nasal Speculum 5 25 Size 2 German Grade Von Klaus
Meso Scale Discovery U-PLEX Human ICOS-L/B7-H2 ASY
The Meso Scale Discovery U-PLEX Human ICOS/L B7-H2 Assay is a multiplex immunoassay kit that enables simultaneous quantitative measurement of human Inducible T cell COStimulator (ICOS) and B7 Homolog 2 (B7-H2) in serum plasma and cell culture supernatants It utilizes MSD s electrochemiluminescent detection technology and provides high sensitivity up to 5 logs of dynamic range and low sample volume requirements This assay allows for the efficient analysis of ICOS and B7-H2 which play important roles in immune regulation
Biochain Institute Inc Paraffin Tissue Section - Human Adult Normal: Spinal Cord, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Revvity Health Sciences Inc AequoZen Human GPR99 Cell Line, CHO-K1 Frozen Cells
AequoZen Human GPR99 Cell Line, CHO-K1 Frozen Cells