Donkey Secondary Antibodies
Biotium STAT5B(STAT5B/2657), CF647 conjugate, 0.1mg/mL
Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96% homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice hav
Biotium CD262 / DR5(DR5/3381), CF647 conjugate, 0.1mg/mL
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated by two distinct cell surface receptors, designated TNF-R1 and TNF-R2, which are expressed on most cell types. TNF function is primarily mediated through TNF-R1 signaling. Both receptors belong to the growing TNF receptor superfamily which includes Fas antigen and CD40. TNF-R1 contains a cytoplasmic motif, termed the death domain , that has been found to be necessary for the transduction of the apoptotic signal. The death domain is also found in several other receptors, including Fas, DR2 (or TRUNDD), DR3 (death receptor 3), DR4 and DR5. TRUNDD, DR4 and DR5 are receptors for the apoptosis-inducing cytokine TRAIL. A non-death domain-containing receptor, designated decoy receptor (DcR1 or TRID), also specifically associates with TRAIL and may play a role in cellular resistance to apoptotic stimuli. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other label
Biotium PAX8 (Renal Cell Marker)(rPAX8/1492), CF647 conjugate, 0.1mg/mL
Recognizes a protein of 62 kDa, identified as PAX8. It is a member of the paired box (PAX) family of transcription factors. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas, and atypical thyroid adenomas. PAX-8 is expressed in the thyroid (and associated carcinomas), non-ciliated mucosal cells of the fallopian tubes, and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. PAX-8 expression is reported in renal tubules as well as renal cell carcinoma, nephroblastoma, and seminoma. PAX-8 antibody may be used as an additional immunohistochemical marker for renal epithelial tumors. Primary antibodies are available purified, or with a
Biotium MALT-1(MT1/410), CF647 conjugate, 0.1mg/mL
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not re
Biotium Parathyroid Hormone (PTH) (N-Terminal)(rPTH/911), CF647 conjugate, 0.1mg/mL
Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2 levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism. Primary antibodies are available purified, or with a selection of fluores
Biotium TSH-Receptor, B-Chain (Thyroid Marker) (TSHRB/1404), CF647 conjugate, 0.1mg/mL
Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targe
Biotium Primary Antibody Neurofilament H rRmdO-20 CF647 1/EA
Neurofilament-H (rRmdO-20) is a recombinant mouse monoclonal antibody that recognizes Neurofilament-H This CF647 antibody conjugate has been validated in Immunofluorescence CF and reg dyes are Biotiums line of next-generation fluorescent dyes with advantages in brightness and photostability
Jackson Immuno Research Labs Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Human IgM Fc5µ Fragment Specific (min X Bov Hrs Sr Prot)
Cy3-AffiniPure F(ab')2 Fragment Donkey Anti-Human IgM Fc5µ Fragment Specific (min X Bov Hrs Sr Prot)
Jackson Immuno Research Labs Cy™5 AffiniPure™ Donkey Anti-Human IgG (H+L), 0.5 mg
Target: HumanHost: DonkeyAntibody Format: Whole IgGSpecificity: IgG (H+L)Minimal Cross Reactivity: Bovine, Chicken, Goat, Guinea Pig, Syrian Hamster, Horse, Mouse, Rabbit, Rat, Sheep Serum ProteinsConjugate: Cyanine Cy™5Product Category: Cyanine Conjugates for Permanent MountingClonality: PolyclonalRRID: AB_2340539
Jackson Immuno Research Labs Fluorescein (FITC) AffiniPure F(ab')₂ Fragment Donkey Anti-Human IgG, Fcγ fragment specific, 1mg
Fluorescein (FITC)-AffiniPure F(ab')2 Fragment Donkey Anti-Human IgG, Fc Fragment Specific (min X Bov,Hrs,Ms Sr Prot)
Jackson Immuno Research Labs Alexa Fluor 594-AffiniPure Donkey Anti-Human IgG Fcγ Fragment Specific (min X Bov Hrs Ms Sr Prot)
Alexa Fluor 594-AffiniPure Donkey Anti-Human IgG Fcγ Fragment Specific (min X Bov Hrs Ms Sr Prot)
Jackson Immuno Research Labs AMCA-AffiniPure F(ab')2 Fragment Donkey Anti-Human IgG Fcγ Fragment Specific (min X Bov Hrs Ms Sr Prot)
AMCA-AffiniPure F(ab')2 Fragment Donkey Anti-Human IgG Fcγ Fragment Specific (min X Bov Hrs Ms Sr Prot)
Jackson Immuno Research Labs Alexa Fluor 488-AffiniPure Donkey Anti-Human IgM Fc5µ Fragment Specific (min X Bov Hrs Sr Prot)
Alexa Fluor 488-AffiniPure Donkey Anti-Human IgM Fc5µ Fragment Specific (min X Bov Hrs Sr Prot)