Mouse Secondary Antibodies
Cayman Chemical A-77636hydrochlorIde 10mg
An agonist of the dopamine D1 receptor (Ki=40 nM); induces activity equal to or greater than dopamine in fish retinas and rat caudate-putman (EC50s = 7.4 and 1.1 nM, respectively); does not show agonist behavior for the D2 receptor expressed in MMQ cells (≤10 μM); induces desensitization of dopamine-stimulated cAMP accumulation and reduces D1 receptor expression by 79% in C-6 glioma cells expressing monkey D1A receptors (10 μM); increases locomotor activity 5.3-fold and reduces disease severity in a MPTP-treated marmoset model of Parkinson's disease (3 μmol/kg s.c.); elicits over a 230% increase in cortical and hippocampal acetylcholine release (4 μmol/kg, s.c.)
Biotium Human IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker) (IGHG4/2042R), CF594 conjugate, 0.1mg/mL
The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lympho-plasmacytic infiltration with the presence of many IgG4-positive plasma cells. IgG4 is overexpressed in inflammatory pseudo-tumor (IPT) and under expressed in inflammatory myofibroblast
Biotium Human IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker) (IGHM/2559R), CF568 conjugate, 0.1mg/mL
This antibody recognizes a protein of 75 kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.Primary antibodies are available purifi
Cayman Chemical -PraeruptrIn A 100mg
A coumarin derivative; prevents LPS-induced increases in IL-1β and TNF-α at 25-100 µM and IL-6 at 25-100 µM; inhibits potassium chloride-induced contraction of isolated rabbit trachea by 50 and 100% at 4.8 and 30 µM, respectively; reduces edema in a croton oil mouse model of inflammation at 0.3 µmol/cm2 applied topically
Miltenyi Biotec, Inc. CD45RC Antibody, anti-human, APC, REAfinity™
Identification and enumeration of CD45RC+ cells by flow cytometry.
This product is subject to the following: Miltenyi Biotec, Inc. Terms and Conditions of Sale For Products and Services
Miltenyi Biotec, Inc. P4HB Antibody, anti-human, Vio B515, REAdye_lease™
Detection of P4HB+ cells.
This product is subject to the following: Miltenyi Biotec, Inc. Terms and Conditions of Sale For Products and Services
