Rabbit Secondary Antibodies
ABclonal Technology PE Rabbit anti-Mouse CD25 mAb
Enables interleukin-2 binding activity and interleukin-2 receptor activity Acts upstream of or within several processes including Notch signaling pathway activation-induced cell death of T cells and regulation of T cell proliferation Located in external side of plasma membrane Is expressed in bone marrow Used to study Sjogren s syndrome and inflammatory bowel disease Human ortholog(s) of this gene implicated in immunodeficiency 41 lymphopenia multiple sclerosis type 1 diabetes mellitus and type 1 diabetes mellitus 10 Orthologous to human IL2RA (interleukin 2 receptor subunit alpha)
ABclonal Technology PE Rabbit anti-Mouse CD38 mAb
This gene encodes a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Knockout mice deficient for this gene display altered humoral immune responses In addition knockout mice exhibit higher locomotor activity and defects in nurturing and social behaviors
ABclonal Technology APC Rabbit anti-Mouse CD25 mAb
Enables interleukin-2 binding activity and interleukin-2 receptor activity Acts upstream of or within several processes including Notch signaling pathway activation-induced cell death of T cells and regulation of T cell proliferation Located in external side of plasma membrane Is expressed in bone marrow Used to study Sjogren s syndrome and inflammatory bowel disease Human ortholog(s) of this gene implicated in immunodeficiency 41 lymphopenia multiple sclerosis type 1 diabetes mellitus and type 1 diabetes mellitus 10 Orthologous to human IL2RA (interleukin 2 receptor subunit alpha)
ABclonal Technology PE Rabbit anti-Mouse CD40 mAb
Predicted to enable antigen binding activity protein domain specific binding activity and ubiquitin protein ligase binding activity Involved in B cell mediated immunity CD40 signaling pathway and cellular calcium ion homeostasis Acts upstream of or within several processes including defense response to other organism positive regulation of B cell activation and positive regulation of interleukin-12 production Located in external side of plasma membrane and intracellular membrane-bounded organelle Part of CD40 receptor complex Is expressed in several structures including alimentary system brain hemolymphoid system gland liver and biliary system and reproductive system Human ortholog(s) of this gene implicated in several diseases including Kawasaki disease autoimmune disease (multiple) end stage renal disease hyperimmunoglobulin syndrome (multiple) and non-Hodgkin lymphoma (multiple) Orthologous to human CD40 (CD40 molecule)
ABclonal Technology FITC Rabbit anti-Mouse CD32
CD32 (Fcgr2) is a 40 kD transmembrane glycoprotein member of the immunoglobulin superfamily The extracellular region of CD32 consists of two Ig C-type domains that binds the Fc region from monomeric IgG with low affinity but binds immune complexes efficiently CD32 can mediate phagocytosis of immune complexes and modulate cell activation CD32 is expressed by Macrophages neutrophils mast cells and B cells
ABclonal Technology APC Rabbit anti-Mouse CD34 mAb
Enables sulfate binding activity Acts upstream of or within leukocyte migration Located in cytoplasm external side of plasma membrane and extracellular region Is expressed in several structures including alimentary system cardiovascular system extraembryonic component genitourinary system and skin Orthologous to human CD34 (CD34 molecule)
ABclonal Technology PE Rabbit anti-Mouse/Rat CD27
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process Involved in negative regulation of apoptotic process and positive regulation of JNK cascade Acts upstream of or within negative regulation of T cell apoptotic process Located in external side of plasma membrane Is expressed in several structures including femur hemolymphoid system intestine pituitary gland and reproductive system Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 2 Orthologous to human CD27 (CD27 molecule)
ABclonal Technology PE Rabbit anti-Mouse CD68 mAb
Involved in several processes including cellular response to lipopolysaccharide cellular response to oxidised low-density lipoprotein particle stimulus and negative regulation of dendritic cell antigen processing and presentation Acts upstream of or within aging and cellular response to organic substance Located in lysosome and plasma membrane Is expressed in several structures including central nervous system embryo mesenchyme heart blood vessel liver and spleen Orthologous to human CD68 (CD68 molecule)
ABclonal Technology PE Rabbit anti-Mouse/Rat CD54
This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1 It participates in the innate immune response
ABclonal Technology PE Rabbit anti-Mouse CD69 mAb
Predicted to enable calcium ion binding activity and identical protein binding activity Located in external side of plasma membrane Orthologous to human CD69 (CD69 molecule)
ABclonal Technology APC Rabbit anti-Mouse/Rat CD54
This gene encodes an integral membrane protein that binds leukocyte adhesion protein LFA-1 It participates in the innate immune response
Jackson Immuno Research Labs Alexa Fluor 647-AffiniPure Rabbit Anti-Mouse IgG Fcγ Fragment Specific
Alexa Fluor 647-AffiniPure Rabbit Anti-Mouse IgG Fcγ Fragment Specific
ABclonal Technology PE Rabbit anti-Mouse TNF-a mAb
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily Members of this family are classified based on primary sequence function and structure This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation In mouse deficiency of this gene is associated with defects in response to bacterial infection with defects in forming organized follicular dendritic cell networks and germinal centers and with a lack of primary B cell follicles Alternative splicing results in multiple transcript variants