Rabbit Secondary Antibodies
ABclonal Technology ABflo 647 Rabbit anti- IgG1
Mouse IgG1 is a subtype of immunoglobulin G antibody that is produced by B cells in response to an antigen It is the most abundant IgG subtype in the serum and plays a crucial role in the adaptive immune response Mouse IgG1 is composed of two heavy chains and two light chains and it is involved in opsonization complement activation and antibody-dependent cell-mediated cytotoxicity It is also involved in the regulation of immune responses including the activation of T cells and the inhibition of B cell activation Mouse IgG1 is widely used in research and diagnostic applications including ELISA Western blotting and immunohistochemistry It is also used in therapeutic applications such as immunotherapy and vaccine development
ABclonal Technology CHDH Rabbit mAb
The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion Variations in this gene can affect susceptibility to choline deficiency A few transcript variants have been found for this gene but the full-length nature of only one has been characterized to date
Jackson Immuno Research Labs Alkaline Phosphatase-AffiniPure Rabbit Anti-Mouse IgG Fcγ Fragment Specific
Alkaline Phosphatase-AffiniPure Rabbit Anti-Mouse IgG Fcγ Fragment Specific
ABclonal Technology S100A12/CGRP Rabbit mAb
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs S100 proteins are localized in the cytoplasm and or nucleus of a wide range of cells and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation S100 genes include at least 13 members which are located as a cluster on chromosome 1q21 This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities The protein includes an antimicrobial peptide which has antibacterial activity
ABclonal Technology TRAF6 Rabbit mAb
The protein encoded by this gene is a member of the TNF receptor-associated factor (TRAF) protein family mediating signal transduction from the TNF receptor superfamily and the Toll IL-1 family It contains a RING domain four zinc-finger motifs a coiled-coil region and a TRAF-C domain This protein transduces signals from receptors like CD40 TNFSF11 and IL-1 and interacts with kinases such as IRAK1 SRC and PKCzeta linking different signaling pathways It plays a key role in the NF-kappaB pathway by activating IkappaB kinase (IKK) in response to proinflammatory cytokines This process requires its interaction with ubiquitin conjugating enzymes UBE2N UBC13 and UBE2V1 Additionally it interacts with the TGF beta receptor complex for Smad-independent activation of JNK and p38 kinases playing a vital role in antiviral and immune responses
ABclonal Technology FXR/NR1H4 Rabbit mAb
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members This protein functions as a receptor for bile acids and when bound to bile acids binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport Alternatively spliced transcript variants encoding different isoforms have been described
ABclonal Technology PE Rabbit anti-Mouse IgM mAb
Enables several functions including antigen binding activity identical protein binding activity and immunoglobulin receptor binding activity Acts upstream of or within several processes including early endosome to late endosome transport immunoglobulin mediated immune response and positive regulation of B cell proliferation Located in external side of plasma membrane extracellular space and perinuclear region of cytoplasm Part of B cell receptor complex and immunoglobulin complex circulating Is expressed in several structures including brain hemolymphoid system and liver Used to study non-Hodgkin lymphoma and type 1 diabetes mellitus Human ortholog(s) of this gene implicated in agammaglobulinemia Orthologous to human IGHM (immunoglobulin heavy constant mu)
ABclonal Technology FCGRT/FCRN Rabbit mAb
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta This protein also binds immunoglobulin G to protect the antibody from degradation Alternative splicing results in multiple transcript variants
ABclonal Technology IL9 Rabbit mAb
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells This cytokine stimulates cell proliferation and prevents apoptosis It functions through the interleukin 9 receptor (IL9R) which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes The gene encoding this cytokine has been identified as a candidate gene for asthma Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness
ABclonal Technology RAB8A Rabbit mAb
This gene encodes a protein in the RAS superfamily a group of small GTP/GDP-binding proteins ( 200 amino acids) involved in intracellular signaling RAB/YPT family members including this protein may help transport proteins from the endoplasmic reticulum to the Golgi and plasma membrane The protein shares high sequence similarity with dog RAB8 (97%) and mouse MEL (96%) and contains the four conserved GTP/GDP-binding sites typical of RAS proteins It also has a C-terminal CAAX motif common in RAS proteins but absent in most RAB/YPT proteins Although originally identified as a transforming gene from a melanoma cell line no clear link between this gene (MEL) and malignant melanoma has been established It is located about 800 kb downstream of MY09B on chromosome 19p13 1
ABclonal Technology GSTA4 Rabbit mAb
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families These enzymes are involved in cellular defense against toxic carcinogenic and pharmacologically active electrophilic compounds At present eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified alpha kappa mu omega pi sigma theta and zeta This gene encodes a glutathione S-tranferase belonging to the alpha class The alpha class genes which are located in a cluster on chromosome 6 are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson s disease Alzheimer s disease cataract formation and atherosclerosis
ABclonal Technology ASCL4 Rabbit mAb
Basic helix-loop-helix transcription factors such as ASCL4 are essential for the determination of cell fate and the development and differentiation of numerous tissues (Jonsson et al 2004 [PubMed 15475265])