Rabbit Secondary Antibodies
ABclonal Technology APC Rabbit anti-Human CD5 mAb
This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system This protein is a type-I transmembrane glycoprotein found on the surface of thymocytes T lymphocytes and a subset of B lymphocytes The encoded protein contains three SRCR domains and may act as a receptor to regulate T-cell proliferation Alternative splicing results in multiple transcript variants encoding different isoforms
Jackson Immuno Research Labs AMCA-AffiniPure F(ab')2 Fragment Rabbit Anti-Human IgM Fc5µ Fragment Specific
AMCA-AffiniPure F(ab')2 Fragment Rabbit Anti-Human IgM Fc5µ Fragment Specific
Jackson Immuno Research Labs Alexa Fluor 647-AffiniPure Rabbit Anti-Human IgG + IgM (H+L) (min X Ms Sr Prot)
Alexa Fluor 647-AffiniPure Rabbit Anti-Human IgG + IgM (H+L) (min X Ms Sr Prot)
ABclonal Technology 488 Rabbit anti-Human AGTR2
This gene encodes a G-protein coupled receptor 1 family member serving as a receptor for angiotensin II It is an integral membrane protein highly expressed in fetuses and neonates but less so in adults except in the brain adrenal medulla and atretic ovary This receptor mediates programmed cell death playing a role in developmental biology and disease pathophysiology Mutations are linked to X-linked cognitive disability SARS-CoV and SARS-CoV-2 infections downregulate ACE2 receptors triggering inflammatory lesions particularly in the lungs The angiotensin AT2 receptor is upregulated in bronchoalveolar lavage samples from COVID-19 patients suggesting its role in inflammation
ABclonal Technology 594 Rabbit anti-Human IL8
The protein encoded by this gene is interleukin-8 (IL-8) a major mediator of inflammation and a member of the CXC chemokine family IL-8 is secreted by macrophages neutrophils eosinophils T lymphocytes epithelial cells and fibroblasts guiding neutrophils to infection sites It is rapidly induced by bacterial and viral products and contributes to the proinflammatory cascade playing a role in systemic inflammatory response syndrome (SIRS) IL-8 is involved in conditions like bronchiolitis cystic fibrosis coronary artery disease and endothelial dysfunction It also promotes tumor migration invasion angiogenesis and metastasis IL-8 binds to its receptor (CXCR2) increasing blood vessel permeability Elevated IL-8 levels correlate with worsened disease outcomes including sepsis This gene is part of a CXC chemokine cluster on chromosome 4q
ABclonal Technology 610 Rabbit anti-Human EGFR
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation Mutations in this gene are associated with lung cancer EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
ABclonal Technology 594 Rabbit anti-Human CDA
This gene encodes an enzyme involved in pyrimidine salvaging The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine respectively It is one of several deaminases responsible for maintaining the cellular pyrimidine pool Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias
ABclonal Technology 488 Rabbit anti-Human FATP1
Enables biotin transmembrane transporter activity efflux transmembrane transporter activity and long-chain fatty acid transporter activity Involved in several processes including carboxylic acid transmembrane transport glycerophospholipid biosynthetic process and lipid transport across blood-brain barrier Located in membrane Part of plasma membrane
ABclonal Technology 594 Rabbit anti-Human CD61
The ITGB3 protein product is the integrin beta chain beta 3 Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain A given chain may combine with multiple partners resulting in different integrins Integrin beta 3 is found along with the alpha IIb chain in platelets Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling
ABclonal Technology PE Rabbit anti-Human CD22 mAb
Predicted to enable CD4 receptor binding activity protein phosphatase binding activity and sialic acid binding activity Involved in B cell activation negative regulation of B cell receptor signaling pathway and regulation of endocytosis Located in early endosome and recycling endosome
ABclonal Technology 488 Rabbit anti-Human CD22
Predicted to enable CD4 receptor binding activity protein phosphatase binding activity and sialic acid binding activity Involved in B cell activation negative regulation of B cell receptor signaling pathway and regulation of endocytosis Located in early endosome and recycling endosome
ABclonal Technology 647 Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology PE Rabbit anti-Human CD1c mAb
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail Alternatively spliced transcript variants of this gene have been observed but their full-length nature is not known
ABclonal Technology 610 Rabbit anti-Human CD2
The protein encoded by this gene is a surface antigen found on all peripheral blood T-cells The encoded protein interacts with LFA3 (CD58) on antigen presenting cells to optimize immune recognition A locus control region (LCR) has been found in the 3 flanking sequence of this gene