Rabbit Secondary Antibodies
ABclonal Technology APC Rabbit anti-Human CD38 mAb
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology 594 Rabbit anti-Human ROR1
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia Alternative splicing results in multiple transcript variants encoding different isoforms
ABclonal Technology APC Rabbit anti-Human TLR3 mAb
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity TLRs are highly conserved from Drosophila to humans and share structural and functional similarities They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity The various TLRs exhibit different patterns of expression This receptor is most abundantly expressed in placenta and pancreas and is restricted to the dendritic subpopulation of the leukocytes It recognizes dsRNA associated with viral infection and induces the activation of NF-kappaB and the production of type I interferons It thus plays a role in host defense against multiple viruses
ABclonal Technology 594 Rabbit anti-Human FceR1a
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules mediators such as histamine that are responsible for allergy symptoms are released This receptor is comprised of an alpha subunit a beta subunit and two gamma subunits The protein encoded by this gene represents the alpha subunit
ABclonal Technology 594 Rabbit anti-Human DLL4
This gene is a homolog of the Drosophila delta gene The delta gene family encodes Notch ligands that are characterized by a DSL domain EGF repeats and a transmembrane domain
ABclonal Technology PE Rabbit anti-Human CD44 mAb
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions cell adhesion and migration It is a receptor for hyaluronic acid (HA) and can also interact with other ligands such as osteopontin collagens and matrix metalloproteinases (MMPs) This protein participates in a wide variety of cellular functions including lymphocyte activation recirculation and homing hematopoiesis and tumor metastasis Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms however the full length nature of some of these variants has not been determined Alternative splicing is the basis for the structural and functional diversity of this protein and may be related to tumor metastasis
ABclonal Technology APC Rabbit anti-Human MERTK
This gene is a member of the MER AXL TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains two Ig-like C2-type (immunoglobulin-like) domains and one tyrosine kinase domain Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP)
ABclonal Technology 488 Rabbit anti-Human CD6
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule The gene product is important for continuation of T cell activation This gene may be associated with susceptibility to multiple sclerosis (PMID 19525953 21849685) Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human FGFR3 mAb
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family with its amino acid sequence being highly conserved between members and among divergent species FGFR family members differ from one another in their ligand affinities and tissue distribution A full-length representative protein would consist of an extracellular region composed of three immunoglobulin-like domains a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain The extracellular portion of the protein interacts with fibroblast growth factors setting in motion a cascade of downstream signals ultimately influencing mitogenesis and differentiation This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia
ABclonal Technology 488 Rabbit anti-Human IgE
IgE is the class of antibodies produced in the lungs skin and mucous membranes It may protect against parasite invasion but it is a major factor in allergic reactions The antigen-specific IgE interacts with mast cells and eosinophils triggers the release of histamine leukotrienes and other substances that lead to the itching sneezing and congestion of allergies - and the life threatening respiratory distress of asthma and anaphylactic shock
ABclonal Technology 594 Rabbit anti-Human SIGLEC9
Predicted to enable monosaccharide binding activity and sialic acid binding activity Predicted to be involved in cell adhesion Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis engulfment Predicted to be located in external side of plasma membrane Predicted to be active in plasma membrane
ABclonal Technology 488 Rabbit anti-Human CD48
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins The encoded protein is found on the surface of lymphocytes and other immune cells dendritic cells and endothelial cells and participates in activation and differentiation pathways in these cells The encoded protein does not have a transmembrane domain however but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor Multiple transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 647 Rabbit anti-Human LAMP2
The protein encoded by this gene is a member of a family of membrane glycoproteins This glycoprotein provides selectins with carbohydrate ligands It may play a role in tumor cell metastasis It may also function in the protection maintenance and adhesion of the lysosome Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins
ABclonal Technology 488 Rabbit anti-Human CD28
The protein encoded by this gene is essential for T-cell proliferation and survival cytokine production and T-helper type-2 development Several alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology 488 Rabbit anti-Human CD75
This gene encodes a member of glycosyltransferase family 29 The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates The protein which is normally found in the Golgi but can be proteolytically processed to a soluble form is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6 CD75 and CD76 This gene has been incorrectly referred to as CD75 Alternative splicing results in multiple transcript variants