Rabbit Secondary Antibodies
ABclonal Technology 594 Rabbit anti-Human IL-5
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils The encoded cytokine plays a major role in the regulation of eosinophil formation maturation recruitment and survival The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases This cytokine functions by binding to its receptor which is a heterodimer whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2 GM-CSF) This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4) interleukin 13 (IL13) and CSF2 This gene IL4 and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31
Jackson Immuno Research Labs Alexa Fluor 594-AffiniPure Rabbit Anti-Human Serum IgA α Chain Specific
Alexa Fluor 594-AffiniPure Rabbit Anti-Human Serum IgA α Chain Specific
ABclonal Technology 647 Rabbit anti-Human FAP
The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family It is selectively expressed in reactive stromal fibroblasts of epithelial cancers granulation tissue of healing wounds and malignant cells of bone and soft tissue sarcomas This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development tissue repair and epithelial carcinogenesis Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology PE Rabbit anti-Human CD177 mAb
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration Mutations in this gene are associated with myeloproliferative diseases Over-expression of this gene has been found in patients with polycythemia rubra vera Autoantibodies against the protein may result in pulmonary transfusion reactions and it may be involved in Wegener s granulomatosis A related pseudogene which is adjacent to this gene on chromosome 19 has been identified
ABclonal Technology 647 Rabbit anti-Human CD75
This gene encodes a member of glycosyltransferase family 29 The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates The protein which is normally found in the Golgi but can be proteolytically processed to a soluble form is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6 CD75 and CD76 This gene has been incorrectly referred to as CD75 Alternative splicing results in multiple transcript variants
ABclonal Technology 488 Rabbit anti-Human CD7
This gene encodes a transmembrane protein which is a member of the immunoglobulin superfamily This protein is found on thymocytes and mature T cells It plays an essential role in T-cell interactions and also in T-cell B-cell interaction during early lymphoid development
Vector Laboratories Polyclonal Rabbit anti‑Human CACNA1C / Cav1.2 Antibody IHC LS‑C403015
Polyclonal Rabbit anti‑Human CACNA1C / Cav1.2 Antibody (IHC) LS‑C403015
ABclonal Technology 488 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
Jackson Immuno Research Labs DyLight 405-AffiniPure Rabbit Anti-Human IgA+IgG+IgM (H+L)
DyLight 405-AffiniPure Rabbit Anti-Human IgA+IgG+IgM (H+L)
ABclonal Technology 450 Rabbit anti-Human CD138
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family The syndecans mediate cell binding cell signaling and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins Altered syndecan-1 expression has been detected in several different tumor types While several transcript variants may exist for this gene the full-length natures of only two have been described to date These two represent the major variants of this gene and encode the same protein
ABclonal Technology 647 Rabbit anti-Human CD70
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family This cytokine is a ligand for TNFRSF27 CD27 It is a surface antigen on activated but not on resting T and B lymphocytes It induces proliferation of costimulated T cells enhances the generation of cytolytic T cells and contributes to T cell activation This cytokine is also reported to play a role in regulating B-cell activation cytotoxic function of natural killer cells and immunoglobulin sythesis
ABclonal Technology 647 Rabbit anti-Human PTH1R
The protein encoded by this gene is a member of the G-protein coupled receptor family 2 This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH) The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system Defects in this receptor are known to be the cause of Jansen s metaphyseal chondrodysplasia (JMC) chondrodysplasia Blomstrand type (BOCD) as well as enchodromatosis Two transcript variants encoding the same protein have been found for this gene
ABclonal Technology APC Rabbit anti-Human CD1B mAb
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail and requires vesicular acidification to bind lipid antigens
ABclonal Technology 647 Rabbit anti-Human CD38
The protein encoded by this gene is a non-lineage-restricted type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5 -diphosphate-ribose an intracellular calcium ion mobilizing messenger The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein This protein has an N-terminal cytoplasmic tail a single membrane-spanning domain and a C-terminal extracellular region with four N-glycosylation sites Crystal structure analysis demonstrates that the functional molecule is a dimer with the central portion containing the catalytic site It is used as a prognostic marker for patients with chronic lymphocytic leukemia Alternative splicing results in multiple transcript variants
ABclonal Technology 647 Rabbit anti-Human CD61
The ITGB3 protein product is the integrin beta chain beta 3 Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain A given chain may combine with multiple partners resulting in different integrins Integrin beta 3 is found along with the alpha IIb chain in platelets Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling