Rabbit Secondary Antibodies
ABclonal Technology 450 Rabbit anti-Human EGFR
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily This protein is a receptor for members of the epidermal growth factor family EGFR is a cell surface protein that binds to epidermal growth factor thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation Mutations in this gene are associated with lung cancer EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
ABclonal Technology 594 Rabbit anti-Human IL-1B
The protein encoded by this gene is a member of the interleukin 1 cytokine family This cytokine is produced by activated macrophages as a proprotein which is proteolytically processed to its active form by caspase 1 (CASP1 ICE) This cytokine is an important mediator of the inflammatory response and is involved in a variety of cellular activities including cell proliferation differentiation and apoptosis The induction of cyclooxygenase-2 (PTGS2 COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2
ABclonal Technology PE Rabbit anti-Human CD138 mAb
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family The syndecans mediate cell binding cell signaling and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins Altered syndecan-1 expression has been detected in several different tumor types While several transcript variants may exist for this gene the full-length natures of only two have been described to date These two represent the major variants of this gene and encode the same protein
ABclonal Technology 488 Rabbit anti-Human SIGLEC9
Predicted to enable monosaccharide binding activity and sialic acid binding activity Predicted to be involved in cell adhesion Predicted to act upstream of or within negative regulation of inflammatory response and negative regulation of phagocytosis engulfment Predicted to be located in external side of plasma membrane Predicted to be active in plasma membrane
ABclonal Technology PE Rabbit anti-Human IL-5 mAb
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils The encoded cytokine plays a major role in the regulation of eosinophil formation maturation recruitment and survival The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases This cytokine functions by binding to its receptor which is a heterodimer whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2 GM-CSF) This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4) interleukin 13 (IL13) and CSF2 This gene IL4 and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31
ABclonal Technology 488 Rabbit anti-Human CD35
Complement receptor type 1 (CR1 CD35) is a type I transmembrane glycoprotein that is expressed on the surface of B cells neutrophils monocytes and renal podocytes As a component of the host s innate immune system CR1 CD35 expressed on neutrophils and monocytes binds to ligands coated with complement opsonins C3b and C4b thereby promoting phagocytosis and pro-inflammatory cytokine production CR1 CD35 also participates in negative regulation of the complement cascade through its ability to promote dissociation of C3 and C5 convertases and by serving as one of multiple cofactors for factor-I-mediated cleavage and inactivation of C3b and C4b
ABclonal Technology 647 Rabbit anti-Human CD204
This gene encodes class A macrophage scavenger receptors which produce three isoforms (1 2 and 3) via alternative splicing These trimeric integral membrane glycoproteins are macrophage-specific and involved in various processes like atherosclerosis Alzheimer s disease and host defense Isoforms 1 and 2 mediate the endocytosis of modified low-density lipoproteins (LDLs) while isoform 3 despite having the necessary domain cannot internalize modified LDL due to altered intracellular processing and trapping within the endoplasmic reticulum Isoform 3 also inhibits the function of isoforms 1 and 2 when co-expressed suggesting a regulatory mechanism for scavenger receptor activity in macrophages
ABclonal Technology 488 Rabbit anti-Human IL9
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells This cytokine stimulates cell proliferation and prevents apoptosis It functions through the interleukin 9 receptor (IL9R) which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes The gene encoding this cytokine has been identified as a candidate gene for asthma Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness
ABclonal Technology PE Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology PE Rabbit anti-Human PTH1R mAb
The protein encoded by this gene is a member of the G-protein coupled receptor family 2 This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH) The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system Defects in this receptor are known to be the cause of Jansen s metaphyseal chondrodysplasia (JMC) chondrodysplasia Blomstrand type (BOCD) as well as enchodromatosis Two transcript variants encoding the same protein have been found for this gene
ABclonal Technology PE Rabbit anti-Human Siglec-8
Sialic acid-binding immunoglobulin (Ig)-like lectins or SIGLECs (e g CD33 (MIM 159590)) are a family of type 1 transmembrane proteins each having a unique expression pattern mostly in hemopoietic cells SIGLEC8 is a member of the CD33-like subgroup of SIGLECs which are localized to 19q13 3-q13 4 and have 2 conserved cytoplasmic tyrosine-based motifs an immunoreceptor tyrosine-based inhibitory motif or ITIM (see MIM 604964) and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM MIM 603492) that mediates an association with SLAM-associated protein (SAP MIM 300490) (summarized by Foussias et al 2000 [PubMed 11095983])
ABclonal Technology 594 Rabbit anti-Human CD33
CD33 a type I transmembrane protein is a sialic acid-binding Ig-like lectin (Siglec-3) of the Ig superfamily and human CD33 binds preferentially to alpha-2 6-linked sialic acid Upon binding to its ligands CD33 transduces an inhibitory signaling through the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its intracellular domain inhibiting cellular function such as phagocytosis In addition CD33 is also involved in other processes such as adhesion Due to its exclusive expression on hematopoietic cells particularly the myeloid lineage and their progenitors CD33 has been actively pursued as a therapeutic target against acute myeloid leukemia (AML) CD33 may also be involved in Alzheimer s Disease
ABclonal Technology 488 Rabbit anti-Human CD161
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation Several genes of the C-type lectin superfamily including the rodent NKRP1 family of glycoproteins are expressed by NK cells and may be involved in the regulation of NK cell function The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins a transmembrane domain and a cytoplasmic domain The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus
ABclonal Technology 647 Rabbit anti-Human CD314
Natural killer (NK) cells are lymphocytes capable of lysing tumor and virus-infected cells without prior activation as well as regulating immunity NK cells express several calcium-dependent (C-type) lectins which influence their function The NKG2 gene family located in the NK complex includes genes expressed in NK cells This gene encodes a transmembrane protein with a C-type lectin domain binding ligands like MHC class I chain-related A and B proteins and UL-16 binding proteins Ligand-receptor interactions activate NK and T cells aiding immune system recognition of stressed cells This protein and its ligands are potential therapeutic targets for immune diseases and cancers Read-through transcription occurs between this gene and the upstream KLRC4 family member in the same cluster
ABclonal Technology 647 Rabbit anti-Human TLR1
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity TLRs are highly conserved from Drosophila to humans and share structural and functional similarities They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents and mediate the production of cytokines necessary for the development of effective immunity The various TLRs exhibit different patterns of expression This gene is ubiquitously expressed and at higher levels than other TLR genes Different length transcripts presumably resulting from use of alternative polyadenylation site and or from alternative splicing have been noted for this gene