Rat Secondary Antibodies
Genscript Corporation Human Lambda Light Chain 2D54
Immunoglobulins (Ig) and free light chains (FLC) is involved in humoral immune response Ig is composed of two identical light chains and two identical heavy chains FLC contains two types kappa free light chain (KFLC) and lambda free light chain (LFLC) The expression of Kappa or Lambda is greatly increased in multiple myeloma or other B cell malignancies It is useful for the identification of certain non-Hodgkin s lymphomas leukemias and plasmacytomas Immunohistochemistry is commonly applied for the detection of free light chains
ABclonal Technology APC/Cy7 anti-h/Mk CD19
This gene encodes a cell surface protein in the immunoglobulin superfamily expressed exclusively on B cell lymphocytes It serves as a marker for pre-B cells with expression decreasing as B cells differentiate into antibody-secreting plasma cells The protein contains two N-terminal Ig-like domains a non-Ig-like domain a transmembrane region and a large cytoplasmic domain It forms a complex with CD21 and CD81 lowering the threshold for antigen-triggered B cell activation which activates the PI3K signaling pathway and calcium release This protein is targeted by CAR T-cells for treating lymphoblastic leukemia Mutations are linked to common variable immunodeficiency 3 (CVID3) causing impaired B-cell differentiation hypogammaglobulinemia inability to respond to antigens and recurrent infections Alternative splicing produces multiple transcript variants encoding distinct isoforms
Azzota Corp Rat/Mouse Intubation 500g
Intubation Platform for Rat or Mouse Rats/Mice Operation Table 500g or less
ABclonal Technology 450 anti-Human CD90/Thy1
This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins The encoded protein is involved in cell adhesion and cell communication in numerous cell types but particularly in cells of the immune and nervous systems The encoded protein is widely used as a marker for hematopoietic stem cells This gene may function as a tumor suppressor in nasopharyngeal carcinoma Alternative splicing results in multiple transcript variants
ABclonal Technology 594 anti-Human CD162/PSGL-1
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P- E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes As such this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins This protein requires two post-translational modifications tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans for its high-affinity binding activity Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response Alternate splicing results in multiple transcript variants
ABclonal Technology CD162/PSGL-1 Rabbit mAb
Involved in leukocyte adhesive activation Acts upstream of or within leukocyte tethering or rolling Predicted to be located in plasma membrane raft and uropod Predicted to be active in plasma membrane Is expressed in brain and thymus primordium Human ortholog(s) of this gene implicated in carotid artery disease Orthologous to human SELPLG (selectin P ligand)
ABclonal Technology PE/Cy7 anti- Ly-6A/E Sca-1
Predicted to enable acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity Acts upstream of or within response to bacterium Located in external side of plasma membrane Is expressed in alimentary system hindlimb tendon liver metanephros and physiological umbilical hernia Used to study osteoporosis Orthologous to human LY6H (lymphocyte antigen 6 family member H)
ABclonal Technology PE Rabbit anti-Human CD90/Thy1
This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins The encoded protein is involved in cell adhesion and cell communication in numerous cell types but particularly in cells of the immune and nervous systems The encoded protein is widely used as a marker for hematopoietic stem cells This gene may function as a tumor suppressor in nasopharyngeal carcinoma Alternative splicing results in multiple transcript variants
ABclonal Technology CD162/PSGL-1 Rabbit mAb
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P- E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes As such this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins This protein requires two post-translational modifications tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans for its high-affinity binding activity Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response Alternate splicing results in multiple transcript variants
ABclonal Technology CD162/PSGL-1 Rabbit PolymAb
The protein encoded by this gene is a proinflammatory cytokine of the IL-1 family that is constitutively found as a precursor within the cytoplasm of a variety of cells including macrophages and keratinocytes The inactive IL-18 precursor is processed to its active form by caspase-1 and is capable of stimulating interferon gamma production and of regulating both T helper (Th) 1 and Th2 responses This cytokine has been implicated in the injury of different organs and in potentially fatal conditions characterized by a cytokine storm In humans IL-18 gene is located on chromosome 11 Alternatively spliced transcript variants encoding different isoforms have been found for this gene
ABclonal Technology APC Rabbit anti- CD162/PSGL-1
Involved in leukocyte adhesive activation Acts upstream of or within leukocyte tethering or rolling Predicted to be located in plasma membrane raft and uropod Predicted to be active in plasma membrane Is expressed in brain and thymus primordium Human ortholog(s) of this gene implicated in carotid artery disease Orthologous to human SELPLG (selectin P ligand)
ABclonal Technology APC/Cy7 anti-h/Mk CD8a
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain Both alpha and beta chains share significant homology to immunoglobulin variable light chains This gene encodes the CD8 alpha chain Multiple transcript variants encoding different isoforms have been found for this gene The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein