Fluorescent in situ hybridization Reagents

A16664-500ul LIMK1

LIM proteins including LIM kinase-1 (LIMK1) contain LIM domains with two zinc fingers likely mediating protein-protein interactions LIMK1 part of a subfamily with two LIM motifs and a kinase domain is a serine/threonine kinase that regulates actin polymerization by phosphorylating and inactivating cofilin It is widely expressed during development and plays a role in cytoskeletal structure axon growth and brain development LIMK1 hemizygosity is linked to impaired visuospatial cognition in Williams syndrome Alternative splicing produces multiple isoforms of this protein

A16664-1000ul LIMK1

LIM proteins including LIM kinase-1 (LIMK1) contain LIM domains with two zinc fingers likely mediating protein-protein interactions LIMK1 part of a subfamily with two LIM motifs and a kinase domain is a serine/threonine kinase that regulates actin polymerization by phosphorylating and inactivating cofilin It is widely expressed during development and plays a role in cytoskeletal structure axon growth and brain development LIMK1 hemizygosity is linked to impaired visuospatial cognition in Williams syndrome Alternative splicing produces multiple isoforms of this protein

AP0387-1000ul Phospho-LIMK1-T5

LIM proteins containing conserved LIM domains with zinc fingers mediate protein-protein interactions LIM kinase-1 (LIMK1) belongs to a subfamily with two N-terminal LIM motifs and a C-terminal kinase domain LIMK1 is a serine/threonine kinase that regulates actin polymerization by phosphorylating and inactivating cofilin an actin-binding factor It is widely expressed during development and is involved in cellular processes related to cytoskeletal structure LIMK1 also promotes axon growth and may play a role in brain development Hemizygosity of LIMK1 is linked to impaired visuospatial cognition in Williams syndrome Alternative splicing generates multiple transcript variants encoding distinct isoforms