Apoptosis Reagents and Kits
Biolegend Alexa Fluor 647 Annexin V
Alexa Fluor 647 Annexin V Reactivity: All mammalian species; Apps: FC; Size: 300 tests
ABclonal Technology Annexin A2 Rabbit pAb
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. Annexin A2 expression has been found to correlate with resistance to treatment against various cancer forms.
Enzo Life Sciences In situ hybridization buffer for HPV probes (Ready-to-Use) (50ml)
In situ hybridization buffer for HPV probes (Ready-to Use) provides a high quality hybridization medium for In situ hybridization analyses using either DNA or oligonucleotide probes labeled with biotin-, or fluorescein-modified nucleotides. Long Term Storage: +4°C.
Biolegend PE/Cyanine7 Annexin V
PE/Cyanine7 Annexin V Reactivity: All mammalian species; Apps: FC; Size: 100 tests
American Research Products Inc ANNEXIN V ER780 DAPI APOP KIT
5000265807 ANNEXIN V ER780 DAPI APOP KIT
American Research Products Inc CASPASE 3 7 KIT FLUOROMETRIC B
5000265851 CASPASE 3 7 KIT FLUOROMETRIC B
Biotium Mitochondrial Marker113-1 Biotin conjugate 0.1mgmL
Mitochondrial Marker113-1 Biotin conjugate 0.1mgmL
Biotium Mitochondrial MarkerMTC02 Biotin conjugate 0.1mgmL
Mitochondrial MarkerMTC02 Biotin conjugate 0.1mgmL
AdipoGen SP600125
Chemical. CAS 129-56-6. Formula C14H8N2O. MW 220.2. SP600125 is an orally active, reversible and ATP-competitive broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 IC50 = 40nM, 40nM and 90nM, respectively. In Jurkat T cells, SP600125 suppressed the phosphorylation of c-Jun with IC50 of 5-10 µM. It has 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB and PKCalpha, and 100-fold selectivity against ERK2, p38, Chk1, EGFR. SP600125 is also a broad-spectrum inhibitor of serine/threonine kinases including hydrocarbon receptor AhR, Mps1, Aurora kinase A, FLT3 and TRKA. SP600125 inhibits cell cycle, autophagy and ferroptosis and activates apoptosis. It shows anti-inflammatory activity by inhibiting the expression of inflammatory genes such as COX-2, IL-2 IFN-gamma and TNF-alpha and has antiviral and neuroprotective properties.
AdipoGen CRT0066101 HCl
Chemical. CAS 1781742-22-0. Formula C18H22N6O . 3HCl. MW 338.4 . 109.4. CRT0066101 is an inhibitor of all three PKD isoforms IC50s = 1, 2.5, and 2 nM for PKD1, PKD2 and PKD3, respectively. It exhibits selectivity for PKD against a panel of >90 protein kinases, including PKCalpha, PKBalpha, MEK, ERK, c-Raf, c-Src and c-Abl. PKD family members play an important role in regulating several cellular processes and activities, including chromatin organization, Golgi function, gene expression, cell survival, adhesion, motility, differentiation, DNA synthesis and proliferation. CRT0066101 shows anticancer activity by blocking cell proliferation, inducing apoptosis, G2/M phase arrest, inhibiting migration and invasion and reducing the viability of several cancer cells both in vitro and in vivo.