Apoptosis Reagents and Kits
Abcam Human DVL2 knockout A549 cell lysate.
Human DVL2 knockout A549 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human Lgals9 (galectin 9/Gal-9) knockout THP-1 cell lysate.
Human Lgals9 (galectin 9/Gal-9) knockout THP-1 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Apexbio Technology LLC Z-WEHD-FMK(Synonyms: Z-WEHD fluoromethyl ketone, Z-WEHD-FMK inhibitor, Caspase-5 inhibitor Z-WEHD-FMK), 1mg, CAS: 210345-00-9.
Z-WEHD-FMK (CAS 210345-00-9) is a peptide-based inhibitor primarily targeting inflammatory caspases including caspase-1 -4 and -5 It irreversibly blocks caspase-mediated proteolytic cleavage interfering with cellular signaling pathways involved in inflammation and apoptosis Studies demonstrate that Z-WEHD-FMK treatment prevents Chlamydia-induced fragmentation of the Golgi apparatus by inhibiting golgin-84 cleavage thereby decreasing bacterial proliferation and altering lipid trafficking to pathogen-containing inclusions This inhibitor is frequently utilized in cell biology and infectious disease research to investigate caspase-related cellular processes and microbial pathogenesis mechanisms
Apexbio Technology LLC Ganetespib (STA-9090)(Synonyms: STA-9090, Ganetespib, STA9090, STA 9090), 5mg, CAS: 888216-25-9.
Ganetespib (STA-9090 CAS 888216-25-9) is a small-molecule inhibitor targeting heat shock protein 90 (Hsp90) It binds competitively to the ATP-binding pocket located at the N-terminal region of Hsp90 disrupting its chaperone activity and subsequently causing degradation of client proteins involved in tumor growth and survival Structurally distinct from geldanamycin-derived inhibitors Ganetespib features a triazolone moiety Preclinical studies have demonstrated antitumor activity across various cancer cell types including lung prostate colon breast cancers melanoma and leukemia highlighting its therapeutic potential for cancer research
Cayman Chemical BIotIn-VAD-FMK 1mg
A biotin-conjugated caspase inhibitor; an affinity probe that allows for detection and immobilization of caspases using the biotin ligand; inhibits caspase-3-like activity in a dose-dependent manner in hepatocytes stimulated with TNF-α and ActD; binds to caspase-3 and caspase-8 in hepatocyte lysates
Abcam Caspase-1 Assay Kit (Fluorometric)
Caspase-1 Assay Kit (Fluorometric)
The product is subject to the following: Abcam Restricted Use Statement
ABclonal Technology Annexin A4/Annexin IV Rabbit pAb
Annexin IV (ANX4) belongs to the annexin family of calcium-dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. ANX4 has 45 to 59% identity with other members of its family and shares a similar size and exon-intron organization. Isolated from human placenta, ANX4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANX4 is almost exclusively expressed in epithelial cells. Several transcript variants encoding different isoforms have been found for this gene.
Apexbio Technology LLC Annexin V-APC/DAPI Apoptosis Kit 20tests
Annexin V-APC/DAPI Apoptosis Kit allow discrimination between cells at various stages of apoptosis and cell death Annexin V is a calcium-dependent phospholipid-binding protein which specifically binds to phosphatidylserine (PS) Under normal conditions PS is located on the inner surface of the cell membrane lipid bilayer but during early apoptosis PS translocates from the inner leaflet to the outer leaflet of the plasma membrane becoming exposed to the extracellular environment By using Annexin V-APC labeling apoptotic cells can be detected easily through flow cytometry or fluorescence microscopy within 15-30 minutes Additionally this kit includes the nuclear stain DAPI which specifically binds to double-stranded DNA to emit blue fluorescence Normally DAPI cannot penetrate intact cell membranes In late apoptotic and dead cells DAPI can cross the compromised membrane to stain the nucleus
ABclonal Technology Annexin A6/Annexin VI
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways The annexin VI gene is approximately 60 kbp long and contains 26 exons It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths It is highly similar to human annexins I and II sequences each of which contain four such repeats Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis Alternatively spliced transcript variants have been described
ABclonal Technology Annexin A6/Annexin VI
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways The annexin VI gene is approximately 60 kbp long and contains 26 exons It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths It is highly similar to human annexins I and II sequences each of which contain four such repeats Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis Alternatively spliced transcript variants have been described
Abcam Human SELENBP1 (Selenium Binding Protein 1/SBP) knockout HeLa cell lysate.
Human SELENBP1 (Selenium Binding Protein 1/SBP) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human SAMD9 knockout A549 cell lysate.
Human SAMD9 knockout A549 cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human STK11 (LKB1) knockout HEK-293T cell lysate.
Human STK11 (LKB1) knockout HEK-293T cell lysate.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Human STK3 (MST-2) knockout HeLa cell lysate.
Human STK3 (MST-2) knockout HeLa cell lysate.
The product is subject to the following: Abcam Restricted Use Statement