Apoptosis Reagents and Kits
Biolegend PE/Cyanine7 Annexin V
PE/Cyanine7 Annexin V Reactivity: All mammalian species; Apps: FC; Size: 25 tests
AdipoGen b-AP15
Chemical. CAS 1009817-63-3. Formula C22H17N3O6. MW 419.4. b-AP15 is a specific deubiquitinase DUB inhibitor. It inhibits ubiquitin-specific-processing protease 14 USP14 and ubiquitin c-terminal hydrolase isozyme L5 UCHL5 UCH37, two 19S regulatory particle proteasome-associated DUBs. It exhibits minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP and BAP1. Has been described to inhibit also the 20S proteasome with an IC50 comparable to that required for inhibiting the 19S regulatory particles. b-AP15 has anticancer properties and blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia. b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells. It induces apoptosis, ER stress and autophagy in several cancer cells. b-AP15 has anti-inflammatory properties inhibiting ERK1/2 and JNK phosphorylation, increasing IkappaBalpha levels and inhibiting NF-kappaB p65.
Cytek Biosciences Inc Caspase-3 7 Kit Amnis
Product Name: Muse Caspase-3/7 Kit
Cytek Catalog Number: MCH100108
Product Class: Guava Muse Reagent
Type: Muse
Size: 100 Tests
AdipoGen b-AP15
Chemical. CAS 1009817-63-3. Formula C22H17N3O6. MW 419.4. b-AP15 is a specific deubiquitinase DUB inhibitor. It inhibits ubiquitin-specific-processing protease 14 USP14 and ubiquitin c-terminal hydrolase isozyme L5 UCHL5 UCH37, two 19S regulatory particle proteasome-associated DUBs. It exhibits minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP and BAP1. Has been described to inhibit also the 20S proteasome with an IC50 comparable to that required for inhibiting the 19S regulatory particles. b-AP15 has anticancer properties and blocks tumor progression in vivo in mice and prevents organ infiltration in mouse models of myeloid leukemia. b-AP15 also renders tumor cells sensitive to TNF-mediated apoptosis by natural killer and T cells. It induces apoptosis, ER stress and autophagy in several cancer cells. b-AP15 has anti-inflammatory properties inhibiting ERK1/2 and JNK phosphorylation, increasing IkappaBalpha levels and inhibiting NF-kappaB p65.
Biolegend PE Annexin V Apoptosis Detection Kit with 7-AAD
PE Annexin V Apoptosis Detection Kit with 7-AAD Reactivity: All mammalian species; Apps: FC; Size: 100 tests
Apexbio Technology LLC Cell-permeable, irreversible pan-caspase inhibitor 187389-52-2. MFCD02684037
Cell-permeable, irreversible pan-caspase inhibitor 187389-52-2. MFCD02684037
Abcam JC-10 Mitochondrial Membrane Potential Assay Kit (Microplate)
JC-10 Mitochondrial Membrane Potential Assay Kit (Microplate)
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC RK-33 2mg 1070773-09-9
RK-33 is a first-in-class small molecule inhibitor of DDX3 (a RNA helicase) and causes G1 cell cycle arrest, induces apoptosis, and promotes radiation sensitization in DDX3-overexpressing cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.