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Molecular tests and associated products used for the clinical diagnosis of adenoviral infections. Includes molecular controls, test kits, conjunctivitis tests, and point-of-care tests.
This antibody reacts with adenovirus. The adenovirus early gene product E1A is a potent stimulator of cellular proliferation, which when overexpressed can overcome the growth-inhibitory effects of TGF-β. The E1A region encodes a series of related proteins (35-46 kDa) with multifunctional capabilities and forms a specific complex with the retinoblastoma tumor suppressor gene product. The E1A and E1B regions together comprise the transforming region of adenovirus. While expression of E1A alone is sufficient to immortalize primary cells, complete transformation requires the additional expression of the E1B region.
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Cell Biolabs' 293AD Cell Line is a permanent line established from primary embryonic human kidney transformed with human adenovirus type 5 DNA. The genes encoded by the E1 region of adenovirus (E1a and E1b) are expressed in these cells and participate in transactivation of viral promoters, allowing these cells to produce high levels of protein. The 293AD Cell Line is derived from the parental 293 cells but selected for attributes that increase adenovirus production. It offers several advantages over the regular 293 cells: (1) Larger cell surface area resulting higher transfection and better yield of adenovirus; (2) Flattened morphology; and (3) Firm attachment to culture plates, ideal for large scale culture and adenoviral production.
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More