General Clinical Chemistry Analyzers and Accessories
Abcam LY2886721, BACE-1 inhibitor, 5MG
MW 390.4 Da, Purity >98%. Potent and selective BACE-1 inhibitor (IC₅₀ = 20.3 nM for recombinant hBACE-1). Human BACE2 is inhibited with an IC₅₀ of 10.2 nM. Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer's Disease. Inhibits production of Aβ in HEK-293 Swe cells (IC₅₀ values are 18.5 nM and 19.7 nM for Aβ1-40 and Aβ1-42 respectively) and in PDAPP neuronal cells (IC₅₀ ~10 nM). Reduces dose-dependently brain levels of Aβ, C99 and sAPPβ in orally administered mouse model and plasma Aβ in dog model. Ppenetrates the blood-brain barrier.
The product is subject to the following: Abcam Restricted Use Statement
Abcam LY2940680 (Taladegib), 5MG
MW 512.5 Da. Potent Hedgehog signaling pathway inhibitor. Smoothened antagonist. Inhibits growth of cancer cell lines containing a disease-relevant Smoothened gene mutation. Has anti-tumor activity in animal models.
The product is subject to the following: Abcam Restricted Use Statement
Abcam Apatinib, 25MG
MW 441.9 Da. Potent and selective inhibitor of VEGFR2, IC₅₀ = 1 nm. Orally bioavailable. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Abcam BAY-299, TAF1 and BRD1 inhibitor, 5MG
MW 429.5 Da, Purity >98%. Potent and selective bromodomain inhibitor of TAF1 (IC₅₀ = 8-13 nM) and BRD1 (IC₅₀ = 6-67 nM). More than 30-fold selective versus BRD9 and ATAD2. More than 300-fold selective versus BRD4. Inhibits BRD1 (IC₅₀ = 0.58 μM) and TAF1 (IC₅₀ = 0.9 μM) binding to Histone H4 in cell-based assays; also inhibits BRD1 (IC₅₀ = 0.83 μM) and TAF1 (IC₅₀ = 1.4 μM) binding to Histone H3.3.
The product is subject to the following: Abcam Restricted Use Statement
Biotium Creatine Phosphokinase2ba6 CF488A conjugate 0.1mgmL
Creatine Phosphokinase2ba6 CF488A conjugate 0.1mgmL
Biotium Creatine Phosphokinase2ba6 CF488A conjugate 0.1mgmL
Creatine Phosphokinase2ba6 CF488A conjugate 0.1mgmL
GENERAL BIOPHYSICS LLC Environmental Chamber with Gas Analyzer for Animal Studies
Environmental Chamber for Mice with Noble Gas MonitoringVolume: 8 liters (supports 10-12 mice).Features: Gas recirculation system with O₂ and CO₂ concentration monitoring, CO₂ scrubbing, integrated noble gas monitor.
Abcam CCT-251921, 1MG
MW 410.9 Da, Purity >=98%. CCT-251921 is a potent, selective, small-molecule modulator of the mediator complex-associated kinases CDK8 and CDK19 (IC₅₀, CDK8 = 2.3 nM; CDK19 = 2.6 nM).
The product is subject to the following: Abcam Restricted Use Statement
Anton Paar Dispersion unit with integrated ultrasonication for liquid measurements in water to disperse particles in liquid medium (up to 2500 µm).
LIQUID FLOW DISPERSION UNITDispersion unit with integrated ultrasonication for liquid measurements inwater to disperse particles in liquid medium (up to 2500 µm).Flexible tank filling volume: 150-600 mL.Automated filling, rinsing, and draining.Minimum requirements to run:- outflow of the liquid (wastewater disposal connection or a tank)Recommended requirements to run:- water supply 0.1 - 3 bar