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Molecular Formula C21H25N5O4S, Purity ≥98%, Formula Weight 443.5, Synonyms: Pevonedistat; An analog of adenosine 5'-monophosphate that selectively inhibits NAE (IC50 = 4.7 nM) and disrupts CRL-mediated protein turnover leading to apoptosis in cancer cells by deregulating S-phase DNA synthesis.
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A potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM), ALK4 (IC50 = 140 nM) and, less effectively, ALK7; suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation
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